Agent teratogenicity

In Paris, the Centre de Renseignements sur les Agents Teratogenes supplies to medical professionals information on teratogenic risk when conception is... 

Sciences Center for the Evaluation of Risks to Human Reproduction Documents Shepard s Catalog of Teratogenic Agents Teratogen Information System Breeding Studies... 

Classification Aromatic carboxylic acid Empirical C9H9CIO3 Formula CH3CIC6H3OCH2COOH Properties Wh. cryst. solid free acid insol. in water, but sodium and amine salts are sol. m.w. 200.63 m.p. 118-119 C Toxicology LD50 (oral, rat) 700 mg/kg, (IV, mouse) 28 mg/kg LDLo (subcut., mouse) 28 mg/kg toxic poison by subcut. and IV routes mod. toxic by ing. primary irritant human systemic effects by ing. (blood pressure decrease, coma) cancer suspect agent teratogen mutagen TSCA listed Hazardous Decomp. Prods. Heated to decomp., emits toxic fumes of Cl ... 

The amino acids L-leucine, T-phenylalanine, L-tyrosine, and L-tryptophan all taste bitter, whereas their D-enantiomers taste sweet (5) (see Amino ACIDS). D-Penicillamine [52-67-5] a chelating agent used to remove heavy metals from the body, is a relatively nontoxic dmg effective in the treatment of rheumatoid arthritis, but T.-penicillamine [1113-41 -3] produces optic atrophy and subsequent blindness (6). T.-Penicillamine is roughly eight times more mutagenic than its enantiomer. Such enantioselective mutagenicity is likely due to differences in renal metaboHsm (7). (R)-ThaHdomide (3) is a sedative—hypnotic (3)-thaHdomide (4) is a teratogen (8). 

TERATOGEN A chcmical or physical agent that can cause defects in a developing embryo or foetus when the pregnant female is exposed to the harmful agent. 

Shepard, T. H. (1992). Catalog of Teratogenic Agents (7th ed.) Johns Hopkins University Press, Baltimore. 

Teratogenic. An agent that alters the normal development of the fetus. 

Antimicrobial agents must be used with caution in pregnant and nursing women. Some agents are either known or likely to be teratogenic (e.g., metronidazole), and others pose... 

Teratogenic potential The ability of an agent to cause harm or malformations to a fetus or embryo. Medications are assigned pregnancy categories based on their teratogenic potential. 

Teratogen An agent or substance that may cause physical defects in the developing embryo or fetus when a pregnant female is exposed to that substance. 

Catalog of Teratogenic Agents, 25 209 Catalysis 5 200-254. See also Acid-base catalysis Catalyst entries Catalytic entries Heterogeneous catalysis Homogeneous catalysis Photocatalysis of aromatic reactions, 16 844 cerium applications, 5 685-688... 

Another location with high prostaglandin-synthase activity and low P450 levels is the fetus, and it has been proposed that the teratogenicities of benzo[a]pyrene and phenytoin are due to cyclooxygenase-mediated bioactivation of these agents (45,46). 

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