Noise detector

It should be noted that attenuation is the reciprocal of amplification and individual manufacturers may use either method to designate the sensitivity setting. 

It should be noted that at the high sensitivity ranges of some detectors, filter circuits are automatically introduced to reduce noise. Under these circumstances the noise level should be determined at the lowest attenuation (or highest amplification) that does not include noise-filtering devices (or at best the lowest attenuation with the fastest response time) and then corrected to an attenuation of unity. 

The sensitivity as defined here is sometimes called the minimum detectable concentration (MDC). This definition is a valid alternative, but it is more appropriate to maintain the use of the 

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Precision The precision of a gas chromatographic analysis includes contributions from sampling, sample preparation, and the instrument. The relative standard deviation due to the gas chromatographic portion of the analysis is typically 1-5%, although it can be significantly higher. The principal limitations to precision are detector noise and the reproducibility of injection volumes. In quantitative work, the use of an internal standard compensates for any variability in injection volumes. 

Detector noise The detection limit for the recording of chromatographically separated substances is determined by... 

Raman scattering is essentially undelayed with respect to the arrival of the incident light, in this technique the detector is activated only during each laser pulse and deactivated at all other times. This allows only Raman signals to be recorded but fluorescence signals and detector noise are gated out (Fig. 19). Improvement in Raman signal to fluorescence ratio has been achieved as illustrated in Fig. 20. The technique, however, at present seems to be restricted by several instrumental limitations [37). 

Detector Linearity Linear Dynamic Range Detector Noise Level... 

There are three different types of detector noise, short term noise, long term noise and drift. These sources of noise combine together to give the composite noise of the detector. The different types of noise are depicted in figure 3. 

Short Term Noise consists of base line perturbations that have a frequency that is significantly higher than the eluted peak. Short term detector noise is not often a serious problem m liquid chromatography as it can be easily removed by an appropriate noise filter without affecting the profiles of the peaks. Its source is usually electronic, originating from either the detector sensor system or the amplifier. 

The detector noise is defined as the maximum amplitude of the combined short and long term noise, measured in millivolts, over a period of fifteen minutes. If a column 4.5 mm i.d. is employed, a flow rate of 1 ml/min is appropriate. The flow rate should be adjusted appropriately for columns of different diameters. The value for the detector noise should be obtained by constructing parallel lines embracing the maximum excursions of the recorder trace over the defined time period as shown in figure 4. The distance between the parallel lines measured in millivolts is taken as the noise level. 

Detect 100% of photons Photon detected as a delta function Large number of pixels Time tag for each photon Measure photon wavelength Measure photon polarization No detector noise fr Up to 99% detected fr One electron for each photon fr Over 377 million pixels 0 No - framing detectors 0 No - provided by optics 0 No - provided by optics 0 Readout noise and dark current... 

Detector noise - The two most signihcant noise sources of a detector are readout noise and dark current. 

Figure 2.5 Illustration of detector noise, shown for (a) an ideal situation, and (b) an example of a real situation.

The average within-group repeatability of 0.5% most likely describes detector noise that leads to misassignments of the integration endpoints and peak-area variability, and can be considered acceptable for low-dose products. 

Peaks 5, 6 and 13 are due to instrumental/detector noise. This would still provide a lot of extraneous information however, the instrumental noise has been eliminated. 

Where Q, is the minimum detectable amount, R the detector noise level and s the detector sensitivity [135,146,151,152]. For a concentration sensitive detector the minimum detectable concentration is the product of Q, and the volumetric gas flow rate through the detector. The minimum detectable amount or concentration is proportional to the retention time, and therefore, directly proportional to the column radius for large values of n. it follows, then, that very small quantities can be detected on narrow-bore columns. 

Concentration assays are often the least demanding, since usually the component to be measured is abundant and minor components scarce. Even if resolution is poor or there is detector noise, accurate measurements of concentration can still be obtained. In concentration assays, the principal requirements are stringency in the precision of sample dilution and measurement of column losses of the major component. Detector calibration, another important issue in concentration assays, has been discussed above. 

FTIR instrumentation is mature. A typical routine mid-IR spectrometer has KBr optics, best resolution of around 1cm-1, and a room temperature DTGS detector. Noise levels below 0.1 % T peak-to-peak can be achieved in a few seconds. The sample compartment will accommodate a variety of sampling accessories such as those for ATR (attenuated total reflection) and diffuse reflection. At present, IR spectra can be obtained with fast and very fast FTIR interferometers with microscopes, in reflection and microreflection, in diffusion, at very low or very high temperatures, in dilute solutions, etc. Hyphenated IR techniques such as PyFTIR, TG-FTIR, GC-FTIR, HPLC-FTIR and SEC-FTIR (Chapter 7) can simplify many problems and streamline the selection process by doing multiple analyses with one sampling. Solvent absorbance limits flow-through IR spectroscopy cells so as to make them impractical for polymer analysis. Advanced FTIR... 

One type of ec detector (the coulometric detector) reacts all of the electroactive solute passing through it. This type has never become very popular (there is only one on the market at the moment). Another type (the amperometric detector) reacts a much smaller quantity of the solute, less than 1%. The currents observed with these detectors are very small (nanoamps), but such currents are not too difficult to measure and the detector has a high sensitivity, considerably higher than that of uv/visible absorbance detectors although not as good as fluorescence detectors. Noise equivalent concentrations of about 10, 0g cm-3 have been obtained in favourable cases. Another advantage of these detectors is that they can be made with a very small internal volume. 

Many common infrared and near-infrared detectors are subject to phenomena that are mainly thermal in origin, and therefore the detector noise is independent of the signal level. 

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