Design strategy chapter

The first chapter provides an overview of process design strategies. Fundamental definitions and a brief review of preparing process flow plans are included. 

These inherently safer design strategies are discussed in more detail in Chapter 3, and examples can also be found in Chapter 4, which discusses inherently safer design opportunities through the life cycle of a chemical process. 

This chapter describes the four main design strategies for development of inherently safer processes ... 

It is worth noting here that inhibitors that interact with enzyme active site functionalities in ways that mimic the structure of covalent intermediates of catalysis can bind with very high affinity. This was seen in Chapter 1 with the example of statine-and hydroxyethylene-based inhibitors of aspartic proteases other examples of this inhibitor design strategy will be seen in subsequent chapters of this text. 

We will not describe the iterative design process in any more detail than this. There are many fine books on the subject, and the interested reader is referred to the list at the end of the chapter for further information. After a brief diversion into alternative design strategies in the next section, we will return to the iterative design process to see how the concepts of materials selection fit into mechanical design. 

This is the first of four General Strategy chapters in which we discuss important points that apply to the whole of synthetic design rather than one particular area. This chapter concerns general principles to help you choose one C-C disconnection rather than another. Even a simple molecule like the alcohol 1, introduced in chapter 1 as a component of the elm bark beetle pheromone, can be disconnected at any of the five marked bonds. 

Remark 3.4. In the context of the present chapter (and of the remainder of the book), the term hierarchical control structure reflects the use of two (or multiple) coordinated tiers of control action, and should not be confused with hierarchical plant-wide controller design strategies (see, e.g. Ponton and Laing 1993, Luyben et al. 1997, Zheng et al. 1999, Antelo et al. 2007, Scattolini 2009, and references therein), which use the term hierarchy to denote a set of guidelines, to be followed in sequence, for designing the control system for a chemical plant. 

The design strategy in Sec. 9.4.1 has been tailored to this state of the art. Chapters 10 and 11 contain all the data that the author could find in the published literature, and present them in a manner that can be readily interpolated. 

Chapter 14 diseusses the use of standard software in more detail and how a design strategy based on exploiting COTS produets (as opposed to basing the design strategy on bespoke software) ean reduee the validation effort required by a pharmaceutical or healthcare company. 

In this chapter, the design strategy, synthesis, pharmacology, and pharmacokinetics of fluorinated conformationally restricted glutamate analogues are described in comparison with those of the corresponding hydrocarbon-based compounds. 

---