Inhibitors and design strategies

A number of design strategies have been applied to EGFR inhibitors and have made it into the clinic and, in the case of lapatinib, onto the market. Due to 

An example of this is provided by the work of Girdler et al. on Aurora kinases.95 In this case, the candidate Aurora kinase inhibitor ZM-447439 (5.26) was incubated with HCT-116 cells, starting with a low concentration of the 

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