Design organization libraries

Screening the encoded library produced interesting structures to build an SAR and to design focused libraries of binders for the artificial receptor, but some limitations of these linkers for applications different from peptide chemistry are clearly evident. The carbonate bond connecting the electrophone tag and the photocleavable linker (Figure 9.8) is sensitive to many organic reaction conditions, and the carboxylate requires an amino- or hydroxy function to be linked to the resin after each synthetic step to be encoded. 

Synthetic Organic Libraries Library Design and Properties... 

From now until Chapter 9 our attention will focus on synthetic organic libraries, which are by far the most relevant libraries produced by combinatorial technologies. Their basic properties and their design by means of computational techniques will be described in this chapter as an introduction to the different synthetic organic library formats, which will be covered in the next chapters. 

SYNTHETIC ORGANIC LIBRARIES LIBRARY DESIGN AND PROPERTIES... 

Computational design/selection tools for focused libraries can significantly reduce the efforts required to optimize preliminary structural information while ensuring the exploitation of the same structural input. The use of these results to refine the structural requirements and to eventually generate better focused libraries will become a key tool for combinatorial scientists working with synthetic organic libraries for different applications. 

Figure 8.6 Design of a synthetic organic library and retrosynthetic studies solution- versus solid-phase formats.

In order to obtain combinatorial materials science libraries, sequential deposition must be coupled with a method to diversify the composition of small areas of the deposition surface. A moving-mask system, originally designed to obtain compositional gradients (20) and then used later for the synthesis of organic libraries (21), has been successfully and repeatedly used for this purpose. The first reported materials library LI (22) used this technique employing eight binary masks M0-M7, as shown in Fig. 11.2. 

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