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Synthetic Organic Libraries Library Design and Properties

5 Synthetic Organic Libraries Library Design and Properties [Pg.165]

From now until Chapter 9 our attention will focus on synthetic organic libraries, which are by far the most relevant libraries produced by combinatorial technologies. Their basic properties and their design by means of computational techniques will be described in this chapter as an introduction to the different synthetic organic library formats, which will be covered in the next chapters. [Pg.165]

So-called primary, or unbiased, libraries will be described first, then focused, or biased or targeted, libraries will be presented and thoroughly discussed. A somewhat intermediate class of synthetic organic libraries, which we call biased-targeted, will also be introduced, and their properties and their usefulness will be highlighted. For each of these three classes there will be a discussion of their rationale, their synthesis, and the selection of the scaffolds and the monomer sets used to build the libraries. [Pg.165]

The fourth section of this chapter will address a fundamental topic, the use of computational chemistry methods to help and to drive the design of each library class. A section for each library class will briefly illustrate all the relevant methodologies and their applications through the discussion of specific examples. [Pg.165]


SYNTHETIC ORGANIC LIBRARIES LIBRARY DESIGN AND PROPERTIES... [Pg.166]


See other pages where Synthetic Organic Libraries Library Design and Properties is mentioned: [Pg.454]    [Pg.14]    [Pg.82]    [Pg.4]    [Pg.363]    [Pg.97]    [Pg.19]    [Pg.399]    [Pg.536]    [Pg.215]    [Pg.724]    [Pg.374]    [Pg.36]   


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