Combinatorial libraries synthetic organic

Combinatorial chemistry is both the philosophical and the practical method with which to create structurally diverse compound libraries. Combinatorial chemistry is defined as that branch of synthetic organic chemistry that enables the concomitant synthesis of large numbers of chemical variants in such a manner as to permit their evaluation, isolation, and identification. Combinatorial chemistry affords techniques for the systematic creation of large but structurally diverse libraries. From a technical perspective, there are several avenues of approach to library creation ... 

Dr. Miguel Quimpere joined BioChem Therapeutic in 1990 as a synthetic organic chemist and has since moved on to data management and molecular modeling, with a particular view to diverse library design and combinatorial chemistry. 

Carlson, R. and Gautun, H. (2005) Combinatorial libraries and the development of organic synthetic methods. PLS modelling to discriminate between successful and failed reaction systems, Chemometr. Intell. Lab. Syst., 78, 113. 

Recent literature contains a multitude of examples of synthetic organic methodologies which have been optimized and applied to the solid-phase synthesis of combinatorial libraries [2]. In fact, the production of a number of these libraries has been realized on such systems as the Multipin SPOC [8], the DIVERSOMER [9] and the OntoBLOCK [10], All three apparatuses allow the automated production of spatially dispersed combinatorial libraries and facilitate the isolation, identification, screening and archiving of single compounds in distinct physical locations which are crucial factors during lead discovery and optimization. 

Sepetov N, Issakova O, Analytical characterization of synthetic organic libraries, in Combinatorial Chemistry and Combinatorial Technologies Methods and Applications (Eds. Fassina G, Miertus S), 237-268, 1998, 2005, Chapter 10, this volume. 

MATHEY Phosphorus-Carbon Heterocyclic Chemistry The Rise of a New Domain McKILLOP Advanced Problems in Organic Reaction Mechanisms OBRECHT Solid Supported Combinatorial and Parallel Synthesis of Small-Molecular-Weight Compound Libraries OSBORN Best Synthetic Methods - Carbohydrates PELLETIER Alkaloids Chemical and Biological Perspectives SESSLER WEGHORN Expanded Contracted and Isomeric Porphyrins WONG WHITESIDES Enzymes in Synthetic Organic Chemistry... 

From now until Chapter 9 our attention will focus on synthetic organic libraries, which are by far the most relevant libraries produced by combinatorial technologies. Their basic properties and their design by means of computational techniques will be described in this chapter as an introduction to the different synthetic organic library formats, which will be covered in the next chapters. 

Computational design/selection tools for focused libraries can significantly reduce the efforts required to optimize preliminary structural information while ensuring the exploitation of the same structural input. The use of these results to refine the structural requirements and to eventually generate better focused libraries will become a key tool for combinatorial scientists working with synthetic organic libraries for different applications. 

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