Desensitization local

Topical anesfliesia involves die application of die anes-flietic to die surface of the skin, open area, or mucous membrane The anesthetic may be applied wifli a cotton swab or sprayed on the area This type of anesthesia may be used to desensitize the skin or mucous membrane to the injection of a deeper local anesthetic. In some instances, topical anesthetics may be applied by the nurse ... 

It is reported in Refs 42 67 that moderate quantities of waxy materials incorporated with such expl materials as HMX, RDX and PETN do not appreciably affect their initiation sensitivity, but do inhibit propagation to expin. Ref 67 further states that no relationship between the specific and latent heats of the desensitizers and its ability to desensitize could be found, and concludes that the desensitizer cannot be regarded merely as a thermal sink. This is somewhat in conflict with results of work in Ref 91, where it is reported that it has been established firmly that the sensitivity of the RDX compositions decreases with increasing specific heats of the additives, and a solid desensitizer functions primarily by absorbing heat from local regions of initiation including any hot spots which arise from adiabatic compression of occluded gas ... 

Saitoh O, Masuho I, Terakawa I et al (2001) Regulator of G protein signaling 8 (RGS8) requires its NH2 terminus for subcellular localization and acute desensitization of G protein-gated K+ channels. J Biol Chem 276 5052-8... 

Iontophoresis has been used to deliver local anesthetics in the field of dentistry. Gangarosa [45] reported the iontophoresis of a 2% solution of lidocaine, with epinephrine (1 100,000) for the local anesthesia for extraction of retained deciduous teeth. Iontophoresis has also been used to desensitize teeth [46]. 

P-ARK An enzyme that phosphoylates the occupied form of a G-protein coupled receptor, e.g. the 6-adrenoceptor, leading to uncoupling of that receptor and desensitization. ARMI age-related memory impairment, arrhythmia (dysrhythmia) An abnormality of heart rhythm or rate of heartbeat, usually caused by disturbance of the electrical impulses and their conduction within the heart. They include ectopic beats (isolated irregular beats), tachycardias (too fast a heartbeat), bradycardias (too slow a heartbeat) and atrial flutter and ventricular fibrillation. Arthus reaction A severe local inflammatory response, a skin reaction characterized by erythema, oedema, necrosis, local haemorrhage. A type III hypersensitivity reaction. Arunlakshana and Schild plot See Schild plot, ascites fluid The fluid that accumulates in the peritoneal cavity during certain pathological conditions, aspiration The withdrawal of fluid or tissue from the body by suction. 

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