Des-y-carboxy prothrombin

The usefulness of determining des-y-carboxy prothrombin by sensitive enzyme immunoassay in the early diagnosis of patients with hepatocellular carcinoma. Cancer 1998 82 1643-1648... 

Shimada, M., Takenaka, K., Fujiwara, Y., Gion, T., Kajiyama, K., Maeda, T., Shirabe, K., Sugimachi, K. Des-y-carboxy prothrombin and a-fetoprotein positive status as a new prognostic indicator after hepatic resection for hepatocellular carcinoma. Cancer 1996 78 2094-2100... 

Naraki, T., Kohno, N., Saito, H., Fujimoto, Y., Ohhira, M., Morita, T. and Kohgo, Y., 2002, y-Carboxyglutamic acid content of hepatocellular carcinoma-associated des-y-carboxy prothrombin. Biochim. Biophys. Acta, 1586 287 - 298. 

Additional parameters Decreased serum values of zinc (105, 196) and selenium (27, 181), thrombopenia or throm-bopathy (128) as well as increased values of endotoxins (33, 35) and homocysteine are also considered to be important laboratory parameters. Increased values of anticardiolipin antibodies are a hint of existing portal vein thrombosis. Determination of aj-foetoprotein (s. pp 106, 778) or des-gamma-carboxy prothrombin (s. p. 779) should be carried out to obtain a basic value, then checked at longer intervals if values increase, they must be monitored at shorter intervals. This also applies if there is a progressive rise in AP and y-GT. 

Kaibori, M., Matsul, Y., Yanagida, H., Yokoigawa, N., Kwon, A.H., Kamlyama, Y. Positive status of alpha-fetoprotein and des-gamma-carboxy prothrombin important prognostic factor for recurrent hepatocellular carcinoma. World X Surg. 2004 28 702 - 707... 

Koike, Y., Shiratori, Y., Sato, S., Obi, S., Teratani, T., Imamura, M., Yoshida, H., Shiina, S., Omata, M. Des-gamma-carboxy prothrombin as a useful predisposing factor for the development of portal vein invasion in patients with hepatocellular carcinoma — A prospective analysis of 227 patients. Cancer 2001 91 561 —569... 

Aoyagi Y, Oguro M, Yanagi M, Mita Y, Suda T, Suzuki Y, et al. Chnicai significance of simultaneous determinations of alpha-fetoprotein and des-gamma-carboxy prothrombin in monitoring recurrence in patients with hepatocellular carcinoma. Cancer 1996 77 1781-6. 

Deyashiki Y, Nishioka Y, Takahashi K, Kosaka Y, Suzuki K. Evaluation of des-gamma-carboxy prothrombin as a marker protein of hepatocellular carcinoma. Cancer 1989 64 2546-51. 

Saitoh, S., Dteda, K., Koida, L, Tsubota, A., Arase, Y., Chayama, K. and Kumada, H., 1994, Serum des-gamma-carboxy prothrombin concentration determination by avidin-biotin complex in small hepatocellular carcinomas. Cancer, 74 2918 - 2923. 

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