Dentate gyrus neurogenesis

The proposed neurogenesis-memory clearance hypothesis is attractive because addition and removal of adult-born neurons in local network architecture could gradually destabilize the stored memory traces. Also, adult-generated neurons within the dentate gyrus, the upstream location in the hippocampus, potentially can amplify the destabilization effects. Coincidently, these newborn neurons are short-lived, typically with a life-span of three weeks in rodents [40], which seems to correlate well with the duration of hippocampal dependence of declarative memories. 

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Cameron, H.A., McEwen, B.S., Gould, E. (1995). Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus. J Neurosci, 15, 4687-92. 

Cameron, H.A., Tanapat, P., Gould, E. (1998). Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway. Neurosci, 82,349-54. 

Banasr, M., , M., Printemps, R., Daszuta, A. (2004). Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone. Neuropsychopharmacology, 29, 450-60. 

Van Praag, H., Kempermann, G., Gage, F.H. (1999). Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci, 2, 266-70. 

Arvidsson, A., Kokaia, Z., Lindvall, O. (2001). N-methyl-D-aspartate receptor-mediated increase of neurogenesis in adult rat dentate gyrus following stroke. Eur J Neurosci, 14, 10-8. 

Kuhn HG, Dickinson-Anson H, Gage FH (1996) Neurogenesis in the dentate gyrus of the adult rat age-related decrease of neuronal progenitor proliferation. J Neurosci 16 2027-2033... 

Fig. 2. Mechanisms of VO(OPT)-enhanced neurogenesis after brain ischemia in the hippocampal dentate gyrus. VO(OPT) inhibits protein tyrosine phosphatase IB, thereby stimulating Akt and ERK signaling. The downstream targets of Akt and ERK include HIF-la, GSK-3/3, and CREB, which are involved in the proliferation, migration, and maturation of the neural progenitor cells.

Liu, J., Solway, K., Messing, R. O., and Sharp, F. R. (1998). Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J. Neurosd. 18, 7768-7778. 

Saxe MD, Battaglia F, Wang JW, Malleret G, David DJ, Monckton JE, et al. Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc. Nat. Acad. Sci. U.S.A. 2006 103 17501-17506. 

Kempeimann G, Brandon EP, GageFH (1998b) Environmental sdm-uladon of 129/SvJ mice causes increased cell proliferadon and neurogenesis in the adult dentate gyrus. Cuir Biol 8 939—942. 

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