Dendritic reticulum cells

Scoazec, J. Y., Berger, F., Magaud, J. P., Brochier, J., Coiffier, B., and Bryon, P. A., The dendritic reticulum cell pattern in B cell lymphomas of the small cleaved, mixed, and large cell types An immunohistochemical study of 48 cases. Hum. Pathol. 20, 124—131 (1989). 

FIGURE 6.2 Immunohistochemical staining of a normal germinal center demonstrating CD23 expression on the dendritic reticulum cells (high-level expressor) and on the mantle zone B cells (low-level expressor). 

CD21 is a useful marker to identify neoplasms of follicular dendritic cells. The antigen density on dendritic reticulum cells is fairly high however, the same antigen is expressed at low levels on mantle zone B cells, which makes an excellent low-level control. 

Carbone A, Manconi R, Poletti A, Volpe R. Heterogeneous im-munostaining patterns of follicular dendritic reticulum cells in human lymphoid tissue with selected antibodies reactive with different cell lineages. Hum Pathol. 1988 19 51-56. 

P450 5A1 is expressed in platelets and also erythroleukemia cells . The enzyme is also found in human monocytes , leukocytes , and kidney interstitial dendritic reticulum cells... 

When performing cytokeratin immunostaining of SLNs, one should use a cocktail such as AE1/AE3 CAM5.2 is less desirable because of the manner in which it stains dendritic cells in the lymph node. Micrometastatic cells occur in small clusters less than 2 mm in diameter within the lymph node or subcapsular sinus, and they need to be distinguished from the dendritic appearance of the interstitial reticulum cells of the lymph node, which are also keratin positive. o Studies witfi larger numbers of patients are needed to discern if the site of lymph node micrometastasis (peripheral sinus versus parenchyma of lymph node) is clinically significant. 

B-cell receptor bovine semm albumin cerium (IV) ammonium nitrate complement dependent cytotoxicity CDS cytotoxic T-lymphocytes l,8-diazabicyclo[5.4.0]undec-7-ene dendritic cell deoxyribonucleic acid epidermal growth factor enzyme-linked immunosorbent assay endoplasmic reticulum ethyl... 

Fig. 2. Representative examples of the appearance of /ocZ-positive cells in the central nervous system at the light and electron microscopic levels. (A) Representative examples of histochemically stained lacZ-positive neurons in the rat cerebral cortex resulting from an injection of retrovirus into the cerebral ventricles of the embryonic d 16 rat telencephalon. Note that the cell bodies and proximal dendrites are intensely stained (modified with pamission from Luskin et al., 1993). (B) Representative example of an immunohistochemicaUy stained neuron in the olfactory bulb resulting Irom a perinatal injection of retrovirus. The IdcZ-positive cell was revealed using a primary antibody to P-galactosidase diaminobenzidine was used as a chromogen to visualize the secondary antibody conjugated to horseradish peroxidase. In most instances immunohistochemistry can be used to label the fine processes of lacZ-positive cells (modified with permission from Luskin, 1993). (C) An electron micrograph showing a ZacZ-positive (left) and unlabeled (right) neuron in the visual cortex from a rat that received an intraventricular injection of retrovirus at E16. The nucleus and nuclear membrane are conspicuously stained and in the cytoplasm the reaction product is associated preferentially with the endoplasmic reticulum, which extends into the apical dendrite (large arrows) and basal dendrite (arrowhead) of the labeled cell (modified with permission from Luskin et al., 1993).

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