Dendritic cell-derived chemokine

Pivarcsi A, Gombert M, Dieu-Nosjean MC, Lauerma A, Kubitza R, Meller S, Rieker J, Muller A, Da Cunha L, Haahtela A, Sonkoly E, Fridman WH, Alenius H, Kemeny L, Ruzicka T, Zlotnik A, Homey B CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure. J Immunol 2004 173 5810-5817. 

Adema GJ, Hartgers F, Verstraten R, de Vries E, Marland G, Menon S, Foster J, Xu Y, Nooyen P, McClanahan T, Bacon KB, Figdor GC. A dendritic cell derived CC chemokine that preferentially attracts naive T cells. Nature 1997 387 713-717. 

The lymph node microenvironment represents a niche where CLL cells interact with different types of cells including monocyte-derived nurse-like cells (NLC), CD3+ CD4+ CD154+ T cells, mesenchymal stromal cells, dendritic cells, and endothelial cells (15). In addition to cell-cell interactions, CLL cells are also exposed to a variety of soluble factors such as antigens, cytokines, and chemokines (2). It is the combination of such signals that renders CLL cells less susceptible to chemotherapy and promotes clonal evolution and drug resistance. Thus, the role of the microenvironment needs to be carefully considered in order to develop novel and more effective therapies for CLL treatment (16). In particular, the efficacy of new drugs must be evaluated under experimental conditions that recapitulate (or at least partially mimic) the CLL microenvironment. 

Vulcano, M. M., Albanesi, C. A., Stoppacciaro A. et al. 2001. Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vitro. Eur J Immunol 31 812-822. 

Kanazawa, N., Nakamura, T., Tashiro, K., Muramatsu, M., Moritta, K., Yoneda, K., Inaba, K., Imamura, S., and Honjo, T. (1999). Fractalkine and macrophage-derived chemokine T cell-attracting chemokines expressed in T cell area dendritic cells. Eur. J. Immunol. 29, 1925-1932. 

Histamine induces CD86 expression and chemokine production in immature human derived monocyte-derived dendritic cells that can be blocked by diphenhydramine and other HI receptor antagonists. 

Chemokine receptors and their ligands. Mo, monocytes, DC, dendritic cells DC (CD34), DC derived from CD34 cells in vitro PMN, neutrophils Eo, eosinophils Ba, basophils Th, T helper Tc, T cytotoxic (act.), activated... 

Zou W, J Borvak, F Marches, S Wei, P Galanaud, D Emilie, TJ Curiel. 2000. Macrophage-derived dendritic cells have strong Thl-polarizing potential mediated by beta-chemokines rather than IL-12. J Immunol 165 4388. 

Kanazawa N, Nakamura T, Tashiro K et al. Fractalkine and macrophage-derived chemokine T cell-attracting chemokines expressed in T cell area dendritic cells. Eur J Immunol 1999 29(6) 1925-32. 

Godiska, R., Chantry, D., Raporl, C. J., Sozzani, S., Allavena, P., Leviten, D., Mantovani, A., and Gray, P. A. (1997) Human macrophage-derived chemokine (MDC), a novel chemoattac-tant for monocytes, monocyte-derived dendritic cells, and natural killer cells. J. Exp. Med. 9, 1595-1604. 

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