Papaverine hydrochloride

As shown in Scheme 26, Papaverine hydrochloride yields a separable mixture of Protopapaverine (67) and the salt norpapaverinium chloride (68) when heated slightly beyond its melting point for several minutes. Molecule 67 can exist as conjugated mesomeric betaine 67A (7-hydroxy form) or as 2-substituted-2//-isoquinolin-6-one 67B (6-hydroxy form) (66TL1177). Similar structures were described as zwitterionic pentacyclic... 

Optamine (Theraplix) P6renan (Sanofi Winthrop) Hydergine (Novartis) Coristin (San Carlo) Hydergina (Sandoz) Ischelium (Polifarma) Ischelium Papaverina (Polifarma)-comb. with papaverine hydrochloride Progeril (Midy)... 

Partially deacetylated chitin, a cellulose-like biopolymer consisting predominantly of N-acetyl-D-glucosamine chains, in the form of films or crosslinked hydrogels has been used for the delivery of drugs (28,29). The suitability of chitin as a vehicle for the sustained release of drugs was examined using indomethacin and papaverine hydrochloride as model drugs (30). In vitro studies showed that over 80% of the indomethacin was released within 7 hr, whereas papaverine hydrochloride dissolved almost immediately. 

FIG. 22 Chemical structures of (a) dextromethorphan hydrobromide, (b) papaverine hydrochloride, (c) quinine hydrochloride, and (d) berberine chloride. 

Cerespan Papaverine hydrochloride Rhone-Poulenc Rorer... 

In a specific instance where the organic medicinal substance is basic in nature e.g., papaverine in papaverine hydrochloride, it is primarily treated with an aqueous solution of a base and subsequently the liberated organic base is extracted with either chloroform or ether. 

Procedure Weigh 20 tablets and crush them in a pestle mortar and find out the average weight of a single tablet. Accurately weigh 0.5 g equivalent of papaverine hydrochloride and dissolve in 15 ml of DW. Add to it 15 ml of 2 M sodium hydroxide and extract with 50 ml of chloroform and then with successive 25 ml quantities of chloroform until complete extraction is affected. Wash the combined extracts with two 5 ml quantities of DW and wash the combined aqueous extract with two 10 ml quantities of chloroform. Add the chloroform to the main chloroform extract, evaporate to a small volume, add 2 ml of absolute ethanol, evaporate to dryness and dry the residue to constant weight at 105°C. 

Peripheral vasodilators nylidrin hydrochloride papaverine hydrochloride pentoxifylline... 

Orphol (Opfermann) papaverine hydrochloride Hydro-Ergot (Interstate) ... 

Paveron (Karlspharma) Papaverine Aguctlant USA Papaverine Hydrochloride... 

Infra-red Spectrum. Principal peaks at wavenumbers 1279,1508, 1263,1026,1292,1238 (papaverine hydrochloride, KBrdisk). 

PAPAVERINE HYDROCHLORIDE PAPAVERINE MONOHYDROCHLORIDE PAPAVERIN-HCL (GERMAN) PAP H PAVABID PAVAGRANT PAVAKEY PAVASED PAVATEST SPASMO-NIT 6,7,3, 4 -TETRAMETHOXY-l-BENZYLISOQUINOLINE HYDROCHLORIDE THERAPAV VASAL VASOSPAN... 

Papaverine Hydrochloride, USP. Papaverine hydrochloride. 6.7-dimelhoxy-l-veratryliso< uinoline hydrochloride. was isolated by Merck in 1848 from opium, in which it occurs to the extent of about Although its natural origin is closely related to morphine, the pharmacological actions of papaverine hydrochloride are unlike those of morphine. Its main effect is as a spasmolytic on smooth muscle, acting as a direct, nonspecific relaxant on vascular, cardiac, and other smooth muscle. Because of its broad antispas-modic action on ACh muscarinic receptors, it is often called a nonspecific antagonist. Papaverine hydrochloride has been used in the treatment of peripheral vascular disorders, but its u.se is limited by lack of potency. 

There is of course no bathochromic shift here in alkaline solutions (difference between morphine hydrochloride [111] and codeine phosphate [801]). In many compounds the relatively weak phenol ether band is considerably overshadowed and barely discernible (mepyramine maleate [306], noscapine hydrochloride [805], papaverine hydrochloride [2408]). 

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