Sustained Delivery and Co-Drugs

While corticosteroids, proven to reduce the incidence of retinal detachment in a rabbit PVR model, have some limited antiproliferative properties, they may play a more important role in stabilizing the blood-retinal barrier and preventing the access of inflammatory mediators (30,71,72). A combination of corticosteroid and 5-FU has the potential advantage of addressing both the inflammation and the proliferation associated with PVR formation. 

Formation of conjugated triamcinolone-5-FU in suspension allows sustained release of both drugs. The efficacy and safety of this combination has been tested 

Speicher MA, Fu AD, Martin JP, von Fricken MA. Primary vitrectomy alone for repair of retinal detachments following cataract surgery. Retina 2000 20 459-464. 

Greven CM, Sanders RJ, Brown GC, et al. Pseudophakic retinal detachments. Anatomic and visual results. Ophthalmology 1992 99 257-262. 

Cowley M, Conway BP, Campochiaro PA, Kaiser D, Gaskin H. Clinical risk factors for proliferative vitreoretinopathy. Arch Ophthalmol 1989 107 1147-1151. 

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