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Sustained-release gene delivery

Labhasetwar, V., 1998, Sustained-release gene delivery systems principles and... [Pg.30]

The challenge of developing successful delivery technologies for gene therapy is a world removed from the simple, sustained-release oral formulations which were the achievements of the first pharmaceutical scientists to specialize in advanced drag delivery technology. The potential, in commercial terms and in terms of human well-being, is too vast to estimate. [Pg.47]

Serum albumin has also been tested as NPs for gene delivery. Mo et al. [88] encapsulated the DNA into human serum albumin (HSA) by a desolvationcrosslinking method to produce DNA-HSA NPs having a mean size of 120 nm and zeta potential of —44 mV. The DNA-HSA NPs were easily taken up by the cells via receptor-mediated endocytosis that involved primarily caveolae pathways. Within the cells, DNA-HSA NPs protected the DNA against nuclease attack and showed sustained release of DNA over 6 days without significant cytotoxicity. The overall transfection rate was found to be fivefold higher than obtained with Lipofectamine. [Pg.64]

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See also in sourсe #XX -- [ Pg.130 ]



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