Delivery nanoparticles application

Keywords Polysaccharides Drug delivery Nanoparticle Chitosan Application... 

Nanoparticles interact with fluids, cells, and tissues. Therefore, checking the toxicity of nanoparticles is a necessity. At the site of final retention in the target organs, nanoparticles may tri er mediators, which then may activate inflammatory or immunological responses. With such reasons, designing the biopol3mier-based nanoparticles with the specific sizes is one of the most important criteria for delivery carrier application. Particle shape, surface charge, and surface feature also play roles in intercellular deliveiy... 

Xylans from beech wood, corncobs, and the alkaline steeping liquor of the viscose process have been shown to be applicable as pharmaceutical auxiliaries [3]. Micro- and nanoparticles were prepared by a coacervation method from xylan isolated from corncobs [150]. The process is based on neutralization of an alkaline solution in the presence of surfactant, which was shown to influence both the particle size and morphology. They are aimed at applications in drug delivery systems. 

However, it has to be realized that biological templates remain inserted in the final nanoparticles and this is not acceptable for many applications. Nevertheless, some recent examples indicate that such biomimetic materials may be suitable for the design of biotechnological and medical devices [32]. For instance, it was shown that silica gels formed in the presence of p-R5 were excellent host matrices for enzyme encapsulation [33]. In parallel, biopolymer/silica hybrid macro-, micro- and nanocapsules were recently obtained via biomimetic routes and these exhibit promising properties for the design of drug delivery materials (see Section 3.1.1) [34,35],... 

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