DECYL METHACRYLATE COPOLYMER

Among the pairs of monomers used in synthesizing block copolymers by this method are MMA/AN, C2F4/ MMA, and HEMA/DMA (HEMA = hydroxyethyl methacrylate and DMA = decyl methacrylate). 

Anderson et al. [59, 75,76] have been pursuing their extensive researches on the biomedical behavior of PEUUs having various formulations modified with hydrophobic acrylate (or methacrylate) polymer or copolymer additives. The most distinguished additive was Methacrol 2138F, which is a copolymer between diisopropylaminoethyl methacrylate and decyl methacrylate [co(DIPAM/DM)] (in a 3-to-l ratio). The protein adsorption assay showed that PEUU (Biomer-type) films loaded or coated with Methacrol or poIy(DIPAM) adsorbed significantly lower amounts of human blood proteins (Fb, IgG, factor VIII, Hageman factor and Alb) than the base PEUU or PEUUs modified by other additives. It was revealed from their experiments that poly(DIPAM) as well as Methacrol exhibited a prominent suppressing effect on the protein adsorption process. 

Besides the overall composition of blends and random copolymers, valuable information can be obtained in the case of block copolymers. If a block copolymer contains a homopolymer fraction, a shoulder or second maximum in the MMD curve can be obtained that should have a different chemical composition. Figure 9 shows the MMD of a block copolymer of methyl methacrylate and decyl methacrylate, in which a second lower molar mass maximum can be identified as poly(decyl methacrylate) (PDMA) by dual detection [37]. The increase in the PDMA content with molar mass in the main fraction is reasonable and corresponds well with what is expected from the synthesis. It is worth noticing that this type of information can only be obtained by the D-RI detector combination, because both PDMA and PMMA have a similar low response in UV. 

Figure 3 Gradient HPLC chromatograms of random decyl methacrylate-methyl methacrylate copolymers. Stationary phase Nucleosil 5 CN,...

Block copolymers comprised of PS and polymethacrylate blocks with aliphatic stearyl or decyl side groups were prepared by the sequential addition of monomers, as shown in Scheme 1. Styrene was polymerized in THF at - 78 °C using s-BuLi as the initiator [11,12]. The nucleophilicity of the living polystyryllithium was reduced by reaction with DPE (in order to avoid reactions with the carbonyl groups), followed by the polymerization of the methacrylate monomer. Stearyl methacrylate, SMA is associated with... 

Decanediol 2-Decyl tetradecanoic acid 4,4 -Diaminostilbene-2,2 -disulfonic acid Dihydroxyethyl cocamine oxide Diisobutyl phthalate Dimethyl hydantoin-formaldehyde polymer Dimethyl hydrogenated tallow amine Dimethyl soyamlne Dodecenylsuccinic anhydride Dodecylhexadecanol Ethoxyethanol acetate Ethylene dioleamide Ethylene glycol Ethylene/VA copolymer 2-Ethylhexyl methacrylate 2-Ethylhexyl oleate 2-Furoic acid... 

Pasch H and Augenstein M (1993) Ghromatographic investigations of macromolecules in the critical range of liquid chromatography 5- Characterization of block copolymers of decyl and methyl methacrylate, Makromol Chem 194 2533-2541. 

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