Diisopropylaminoethyl methacrylate

Some of recent papers by Ratner et al. [63, 64] revealed that there are significant differences in the surface chemistry of Biomer lots. The surface of some lots was dominated by poly(diisopropylaminoethyl methacrylate) (DPAEMA or DIPAM), a high molecular weight UV stabilizer, which was absent from some older lots [65]. Ratner et al. carried out comparative studies on in vitro enzymatic and oxidative degradation of two lots of Biomer, BSU 001 and BSP 067. Lot BSU 001 contains both DPAEMA and an antioxidant, Santowhite powder, while BSP 067 contains only the antioxidant. It was found that DPAEMA retarded the enzymatic degradation process, but accelerated oxidative degradation. 

Anderson et al. [59, 75,76] have been pursuing their extensive researches on the biomedical behavior of PEUUs having various formulations modified with hydrophobic acrylate (or methacrylate) polymer or copolymer additives. The most distinguished additive was Methacrol 2138F, which is a copolymer between diisopropylaminoethyl methacrylate and decyl methacrylate [co(DIPAM/DM)] (in a 3-to-l ratio). The protein adsorption assay showed that PEUU (Biomer-type) films loaded or coated with Methacrol or poIy(DIPAM) adsorbed significantly lower amounts of human blood proteins (Fb, IgG, factor VIII, Hageman factor and Alb) than the base PEUU or PEUUs modified by other additives. It was revealed from their experiments that poly(DIPAM) as well as Methacrol exhibited a prominent suppressing effect on the protein adsorption process. 

PDPAEMA poly(N,N-diisopropylaminoethyl methacrylate) PCEMA poly(cinnamoylethyl methacrylate)... 

They used amphiphilic methacrylate polymer with a ternary amino group, poly(A,A-diisopropylaminoethyl methacrylate (DlPAM)-co-n-decyl methacrylate (DMA)) (PDD), composed of 25 unitmol% of DMA in the polymer as a polymeric additive to SPU. The content of the PDD in the SPU was in the range of 1-5 wt%. The surface characteristics of the SPU/PDD polymer alloy were examined by XPS and dynamic contact angle measurements with water. These evaluations revealed that the PDD was located on the surface of the polymer alloy. This induced a more hydrophilic and movable surface compared with untreated SPU. Protein adsorption from human plasma was also reduced on the surface of the SPU/PDD polymer alloy. During the blending process, the solubility of the polymer added to the SPU is important. The solubility parameter of the polymer is one of the factors used to estimate the blending state of both polymers. 

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