Darvon Compound-65

Propoxyphene Aspirin (Darvon Compound-65, Darvon-N w/ Aspirin)... 

Propoxyphene (Darvon) Propoxyphene Acetaminophen (Darvocet) Propoxyphene Aspirin (Darvon Compound-65/ Darvon-N + Aspirin) [C-IV] [Narcotic Analgesic]... 

Propoxyphene/aspirin or acetaminophen (Darvon Compound-65, others). Note This product is not recommended. 

HYDROCHLORIDE/ASPIRIN/CAEFEINE (Darvon compound-65 pulvules 65 mg propoxyphene hydrochloride, 389 mg aspirin, 32.4 caffeine)... 

Darvon (Lilly) Darvon Compound (aaiPharma) Develin ... 

Note Darvocet is propoxyphene and acetaminophen Darvon Compound is propoxyphene and aspirin... 

Coricidin D, Darvon Compound, Disprin, Ecotrin, Avage tazarotene... 

Darvon Compound aspirin, propoxyphene Deplin L-methylfolate... 

I was given x-rays, blood tests, throat cultures, and Darvon Compound 65mg. 4 times a day. 

Salicylates directly stimulate the respiratory center in the medulla. This is characterized by an increase in depth and a pronounced increase in respiration rate. This can be seen with plasma salicylate concentrations of 350 fjbg/mL and marked hyperventilation occurs when the level approaches 5(X) fig/mL. When a barbiturate or opioid fe.g., fiorinal or darvon compound 32) is present, then central respiratory depression will prevent hyperventilation, and the salicylate-induced uncoupling of oxidative phosphorylation will be associated with a marked increase in plasma PCO2 and respiratory acidosis. 

Licata AA, Bartter FC pirc olactone-induced gynaeccmastia related to allergic reaction to Darvon Compound Lancet (1976) ii, 905. 

An example of a problem solving tree for the synthesis of Darvon appears in Figure 3. The tree contains both AND nodes and OR nodes (7). The AND branches, connected by double arcs, indicate that both compounds are required to make the compound above them. The OR branches (there are three OR paths to make compound II) indicate different routes for making the compound. The terminal nodes corresponding to starting materials are enclosed in boxes. At present, a branch is terminated when the number of clauses in the clause list, the internal representation of the goal, is less than or equal to six or the clause list matches the clause list of a starting material molecule. 

Pentazocine (Talwin, Talwin Compound, Talwin NX) Propoxyphene (Darvon) Propox5phene Acetaminophen (Darvocet)... 

Among the compounds that fall within this class are hydrocodone (e.g., Vicodin), oxycodone (e.g., OxyContin—an oral, controlled-release form of the drug), morphine, fentanyl, codeine, and related medications. Morphine and fentanyl are often used to alleviate severe pain, while codeine is used for milder pain. Other examples of opioids prescribed to relieve pain include propoxyphene (Darvon) hydromorphone (Dilaudid) and meperidine (Demerol), which is used less often because of its side effects. In addition to their effective pain-relieving properties, some of these medications can be used to relieve severe diarrhea (for example, Lomotil, also known as diphenoxylate) or severe coughs (codeine). 

The prototypical opioid is morphine (A.137) (Figure A.39). Isolated in a crude form, called opium, morphine has been recognized as a potent pain killer for thousands of years. Although effective, morphine has a low oral availability (F = 25%). Two common derivatives of morphine include hydrocodone (Vicodin, A.138) and oxycodone (A.139), both of which have oral availabilities of greater than 75%. Oxycodone is often sold in an oral continuous-release form under the trade name of OxyContin. Not all opioids are semisynthetic derivatives of morphine. Dextropropoxyphene (Darvon, A.140) and tramadol (Tramal, A.141) are fully synthetic opioids. Both compounds preserve the pharmacophore of morphine as described in the morphine rule (see Chapter 11). Dextropropoxyphene and tramadol are depicted in Figure A.39 to highlight possible pharmacologically active conformations that resemble morphine. 

Esters of Darvon alcohol" and its enantiomer are the drugs Darvon and Novrad (see p. 4Q3)—hence the ready availability ofthiS compound. 

Presently, the system is capable of handling compounds of the order of complexity of Darvon,... 

A congener of isomethadone, propoxyphene (Darvon), was synthesized and introduced as a hoped-for nonaddicting, safer drug for medium severity pain. In view of present knowledge with this compound, the earlier claims that tolerance did not develop even on prolonged administration, and that doses in up to 50 times therapeutic range have not been fatal, stretches credulity to the utmost. The absence of any structural resemblance to morphine was even emphasized. 

Synthetic compounds, pentazocine and Darvon, which have morphine-like activity, and their effects on the pituitary-adrenocortical system. Morphine-like inhibitory effect on histamine ACTH-releasing action... 

S,3R)-4-Dimethy]amino-3-methyI-l,2-diphenyl-2-butanol (7) is a commercially available compound which is produced on an industrial scale because of the analgesic effects of its esters6. It has also been called dextrocarbinol base, or Darvon alcohol, or Chirald. It can be prepared from propiophenone by Mannich reaction with subsequent addition of benzylmagnesium chloride6. Resolution is achieved with ( — )-10-camphorsulfonic acid. Applications include enantioselective reduction of ketones by complex hydrides modified with this amino alcohol8,9 and catalysis in the addition of zinc alkyls to carbonyl compounds (Section D. 1.3.1.4.). 

Outline a racemic synthesis of Darvon (below), an analgesic compound whose use has been discontinued, starting with ethyl phenyl ketone. 

Another example is propoxyphene [33]. The (2R,3S)-enantiomer, sold as the hydrochloride and once marketed as Darvon , is an analgesic. The 2S,3R enantiomer is an antitussive and was once marketed as Novrad . Today, neither is marketed in the United States. Darvon was removed in 2010 and Novrad removed about thirty years earlier. The scientists at Lilly who discovered these compounds were clever in their naming. NOVRAD is the mirror image of the name, DARVON. 

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