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ISIS Pharmaceuticals

Despite these intense efforts to test different chemical modifications, there is so far little success in developing potent and safe antivirals. For hepatitis C virus (HCV), McHutchison et al. reported in vivo side effects of a 20-nucleotide PS-modified ohgonucleotide (ISIS-14803) (McHutchison et al. 2006). In a test group of 28 patients, only 3 patients responded to the treatment by a reduction in the HCV viral load. The researchers concluded that further studies are needed to evaluate this novel agent and its side effects. Previously, ISIS Pharmaceuticals reported a 3.8 log reduction in plasma virus in patients with chronic HCV infection, using ISIS-14803 (www.isispharm.com). [Pg.247]

Figure 3.9 Mode of action for antisense drags. An example is Fomivirsen (Vitravene, Isis Pharmaceuticals), which is a 21-nucleotide phosphorothioate that binds to the complementary mRNA of cytomegalovirus and blocks the translation process. Cytomegalovirus is a virus that belongs to the herpes group. (Source Chang YT. Keyword of the Post Genomic Era—Library, New York University, New York, 2002. http //www. nyu.edu/classes/ytchang/book/e003.html [accessed September 10, 2002].)... Figure 3.9 Mode of action for antisense drags. An example is Fomivirsen (Vitravene, Isis Pharmaceuticals), which is a 21-nucleotide phosphorothioate that binds to the complementary mRNA of cytomegalovirus and blocks the translation process. Cytomegalovirus is a virus that belongs to the herpes group. (Source Chang YT. Keyword of the Post Genomic Era—Library, New York University, New York, 2002. http //www. nyu.edu/classes/ytchang/book/e003.html [accessed September 10, 2002].)...
Isis Pharmaceuticals ISIS 301012 ApoB High cholesterol Phase II... [Pg.82]

Ibis BioSciences ISIS Pharmaceuticals 1891 Rutherford Road Carlsbad, CA 92008 USA... [Pg.463]

Example 56 the Isis Pharmaceutical group in their extensive investigations of antisense oligonucleotides as therapeutics has described the synthesis of 3 -C-methylene nucleoside phosphonoamidites for the new backbone modification of oligonucleotides [90]. This paper gives good insight into tricoordinate phosphorus and related H-phosphonate chemistry in the service of nucleotide synthesis. [Pg.133]

Isis Pharmaceuticals Chemistry/Formulations, http // www.isispharm.com/Antisense-Technology/ Antisense-Drug-Discovery-Platform/Medicinal-Chemistry. htm (accessed August 2012). [Pg.148]

Alicaforsen - Isis Pharmaceuticals Antisense oligonucleotide Phase 3 Inhibitor of intracellular adhesion molecule-1 (ICAM-1) Crohn s disease... [Pg.227]

Scott P. Henry, PhD, DABT, Isis Pharmaceuticals, Inc., 1896 Rutherford Road, Carlsbad, CA 92008 shenry isisph.com... [Pg.1099]

The authors thank their colleagues for help in this work, especially Frederick Hutchison, Michael Murphy, Dr. Abdul Weiss, Dr. Stefan Fischer-Fr uhholz, Dr. Wolfgang Demmer, and Dr. Nussbaumer at Sartorious Corporation, and William E. Leitch II, Patricia De Leon, Dr. Susan Srivatsa, Dr. Yogesh S. Sanghvi, and Dr. Douglas L. Cole at Isis Pharmaceuticals. [Pg.471]

Cole, D. L. (1999). Keynote address—GMP manufacturing of antisense oligonucleotides at Isis Pharmaceuticals for clinical trials and the marketplace Yesterday, today and tomorrow. IBC Conf. Oligonucleotide Pept. Manuf. Strategies, San Diego, CA, 1999. [Pg.533]

Douglas L. Cole (511) Development Chemistry and Pharmaceutical Development, Isis Pharmaceuticals, Inc., Carlsbad, California 92008... [Pg.734]

V. T Ravikumar and 6. Ross, Department of Chemistry, Isis Pharmaceuticals, Carlsbad, CA 92008. [Pg.268]

Lendell L. Cummins, Ibis Therapeutics, A Division of Isis Pharmaceuticals, 1891 Rutherford Road, Carlsbad, CA 92008... [Pg.562]

See other pages where ISIS Pharmaceuticals is mentioned: [Pg.40]    [Pg.6]    [Pg.177]    [Pg.9]    [Pg.1347]    [Pg.131]    [Pg.248]    [Pg.424]    [Pg.425]    [Pg.113]    [Pg.570]    [Pg.580]    [Pg.553]    [Pg.562]    [Pg.564]    [Pg.16]    [Pg.469]    [Pg.512]    [Pg.513]    [Pg.692]    [Pg.735]    [Pg.286]    [Pg.283]   
See also in sourсe #XX -- [ Pg.494 , Pg.507 ]

See also in sourсe #XX -- [ Pg.131 ]

See also in sourсe #XX -- [ Pg.77 , Pg.190 ]



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