Cytidine diphosphocholine

Cytamen cyanocobalamin. cytarabine [ban, inn. jan, usan] (cytarabine hydrochloride [usan] Ara C Cytosar Cytosar-U ) is an antimetabolite cytotoxic ANTICANCER and ANTIVIRAL AGENT isolated from the mushroom Xerocomm nigromaculatus. It works by interfering with pyrimidine synthesis. Clinically, it can be used sys-temically in anticancer treatment mainly of acute leukaemia, cytidine diphosphate choline dticoline. cytidine diphosphocholine dticoline. cytisine is an alkaloid with CNS STIMULANT, RESPIRATORY STIMULANT and psychoactive properties. It has been used clinically as a respiratory stimulant in Russia. It is a common cause of poisoning by the seeds of Cytisus laburnum. 

The type II pneumocytes synthesize phosphatidylcholine in a fashion quite different from that in other cells. Most other cells synthesize phosphatidylserine from cytidine diphosphate diacylglycerol and serine. The phosphatidylserine is then decarboxylated to yield phosphatidyl ethanoiamine. The final step is the successive donation of three methyl groups via S-adenosylmethionine to form phosphatidylcholine. The pulmonary biosynthetic pathway is shown in Figure 54-2. The enzyme choline phosphotransferase forms PC directly from cytidine diphosphocholine and diacylglycerol. Phosphatidylinositol formation peaks at about 35 weeks. As PI decreases in concentration, PG begins to increase. 

Cytidine diphosphocholine, CDP-choline, active choline the activated form of choline, which is biosynthesized from phosphocholine and CTP. See Membrane lipids (biosynthesis). 

Cytidine 5 -(trihydrogen diphosphate) hydroxide mono[2-(trimethylammo-nio) ethyl] ester. Choline hydroxide 5 -ester with cytidine 5 -(trihydrogen pyrophosphate) inner salt. CDP-Choline. Cytidine diphosphocholine. CiticoUne, INN, JAN. Cereb. Citidoline. Colite. Cyscholin. Nicholin [987-78-0]... 

Cytidine cyclic 3, 5 -(hydro n phosphate), C-163 Cytidine cyclic 2, 3 -(hydro n phosphate), C-202 Cytidine 2 -(dihydro n phosphate), C-203 Cytidine 3 -(dihydio n phosphate), C-204 Cytidine 5 -(dihydio n phosphate), C-205 Cytidine diphosphate choline, C-207 Cytidine diphosphate ethanolamine, C-208 Cytidine diphosphate glycerol, C-209 Cytidine 5 -diphosphate, C-206 Cytidine diphosphocholine, C-207... 

Ferris et al., 1982) and with phosphatidylcholines (Bartus et al., 1982) have been reported to be negative or at least equivocal. Although not yet subject to clinical trials for treatment of AD, cytidine-5 -diphosphocholine, a major precursor in the synthesis of phosphatidylcholines, phosphati-dylserines and phosphatidylethanolamines in cell membranes, affects the synthesis and levels of cell membrane phospholipids in PC-12 cells when simultaneously incubated with choline (Lopez G.-Coviella and Wurtman, 1992) and in brain of mice after long-term treatment for 27 months (Lopez... 

Adibhatla RM, Hatcher JF, Dempsey RJ (2004) Cytidine-5 -diphosphocholine affects CTP-phosphocholine cytidylyltransferase and lyso-phosphatidylcholine after transient brain ischemia. J Neurosci Res 76 390-396... 

Methylcytidine, 3-deazacytidine/ l-P-o-arabinofuranosylcytosine 2, 5 -phosphate/ cytidine 5 -diphosphocholine(sodium salt), thymidine 3, 5 -(dimethylphosphoramidate), 4-a-D-erythrofuranosyl-1 (4-tolyl)imidazo-... 

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