Cytidine diphosphate choline

Common Name Citidoline cytidine diphosphate choline Structural Formula ... 

The pH of 1.2 liters of filtrate containing 3.B mg/ml of cytidine diphosphate choline, obtained by removing solid matters from the culturing liquor, was adjusted to a pH of B.5 with a 0.5N KOH solution. The filtrate was passed through a column of strongly basic anion exchange resin, Dowex 1 x 2 (formic acid type). After washing the resin with water, a formic acid... 

Choline and ethanolamine are activated in much the same way as are sugars. For example, choline can be phosphorylated using ATP (Eq. 17-58, step a) and the phosphocholine formed can be further converted (Eq. 17-58, step b) to cytidine diphosphate choline. Phosphocholine is transferred from the latter onto a suitable acceptor to form the final product (Eq. 17-58, step c). Tire polymerization pattern differs from that for polysaccharide synthesis. When the sugar nucleotides react, the entire nucleoside diphosphate is eliminated (Eq. 17-56), but CDP-choline and CDP-ethanolamine react with elimination of CMP (Eq. 

Phosphatidylserine, L-a-glyceryl-phosphorylcholine, and cytidine diphosphate choline have shown positive effects. 

Common Name Citidoline Cytidine diphosphate choline... 

Cytamen cyanocobalamin. cytarabine [ban, inn. jan, usan] (cytarabine hydrochloride [usan] Ara C Cytosar Cytosar-U ) is an antimetabolite cytotoxic ANTICANCER and ANTIVIRAL AGENT isolated from the mushroom Xerocomm nigromaculatus. It works by interfering with pyrimidine synthesis. Clinically, it can be used sys-temically in anticancer treatment mainly of acute leukaemia, cytidine diphosphate choline dticoline. cytidine diphosphocholine dticoline. cytisine is an alkaloid with CNS STIMULANT, RESPIRATORY STIMULANT and psychoactive properties. It has been used clinically as a respiratory stimulant in Russia. It is a common cause of poisoning by the seeds of Cytisus laburnum. 

In the natural synthesis of phosphatidyl choline, the first step is believed to be the phosphorylation of choline, which itself has strongly basic properties of a tetraalkylammonium hydroxide. This is followed by reaction with cytidine triphosphate to give cytidine diphosphate choline, which in tnrn reacts with 1,2 diglyceride which is present (11.101). 

This enzyme catalyses sphingomyelin synthesis from cytidine diphosphate choline. The sphingomyelins ate an important class of structural phospholipids found in cell membrane structures. 

CDP-chollna cytidine diphosphate choline. See Membrane lipids (biosynthesis). 

Cytidine cyclic 3, 5 -(hydro n phosphate), C-163 Cytidine cyclic 2, 3 -(hydro n phosphate), C-202 Cytidine 2 -(dihydro n phosphate), C-203 Cytidine 3 -(dihydio n phosphate), C-204 Cytidine 5 -(dihydio n phosphate), C-205 Cytidine diphosphate choline, C-207 Cytidine diphosphate ethanolamine, C-208 Cytidine diphosphate glycerol, C-209 Cytidine 5 -diphosphate, C-206 Cytidine diphosphocholine, C-207... 

The biosynthesis of sphingosine and the formation of ceramides have already been discussed. The last step in the biosynthesis of sphingomyelins (see Fig. 3-39) involves cytidine diphosphate choline as a phosphate donor, in a reaction similar to that involved in the biosynthesis of lecithin. Scribney and Kennedy have found a chicken liver enzyme, now called the PC ceramide transferase, which catalyzes the following reaction ... 

A mixture of p-toluenesulfonyl chloride and dimethylformamide added to a mixture of choline phosphate and dimethylformamide, shaken 10 min. at room temp, to obtain a viscous soln. in the minimum amount of solvent, cytidine 5 -phosphate added, stirred 1 hr. at room temp., dil. with water, and the pH adjusted to 9.5 with coned, aq. NHg cytidine diphosphate choline. Y 59%. K. Kikugawa and M. Ichino, Chem. Pharm. Bull. 19, 1011 (1971) with thionyl chloride-dimethyl-formamide s. ibid. 19, 2466. 

These finding brought triglyceride synthesis in line with the synthesis of phospholipids, which was shown by Smith et al. (1957) to proceed by removal of the phosphate from phosphatidic acid, with the formation of an a )3-diglyceride. Diglyceride can now be converted into phospholipid, by cytidine-diphosphate-choline or ethanolamine (Kennedy and Weiss 1956) or into neutral triglycerides by the addition of one more fatty acid, derived from fatty acyl-coenzyme A. (Weiss and Kennedy 1956, 1960). 

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