Cycloserine Alcohol

CYCLOSERINE ALCOHOL Risk of fits Additive effect cycloserine can cause fits Warn patients to drink alcohol minimally while taking cycloserine... 

Hypersensitivity to cycloserine epilepsy depression severe anxiety psychosis severe renal insufficiency excessive concurrent use of alcohol. 

Drugs that may interact with cycloserine include alcohol, ethionamide, and isoniazid. 

As illustrated by the examples in Table 3.9, resin-bound 4-alkoxybenzylamides often require higher concentrations of TFA and longer reaction times than carboxylic acids esterified to Wang resin. For this reason, the more acid-sensitive di- or (trialkoxy-benzyl)amines [208] are generally preferred as backbone amide linkers. The required resin-bound, secondary benzylamines can readily be prepared by reductive amination of resin-bound benzaldehydes (Section 10.1.4 and Figure 3.17 [209]) or by A-alkyla-tion of primary amines with resin-bound benzyl halides or sulfonates (Section 10.1.1.1). Sufficiently acidic amides can also be A-alkylated by resin-bound benzyl alcohols under Mitsunobu conditions (see, e.g., [210] attachment to Sasrin of Fmoc cycloserine, an O-alkyl hydroxamic acid). 

Enrichment broths have consisted of brain heart infusion (BHI) with cysteine and yeast extracts (Songer et al., 2009) and Oxoid C. difficile medium without agar (Rodriguez-Palacios et al., 2009 Weese et al., 2010 Table 3.1). These enrichment media may be supplemented with cefoxitin ( 16 pg/ml) and cycloserine ( 500 gg/ml) or moxalactam (32 pg/ml) and norfloxacin (12 gg/ml). Alcohol shock and subculture on commercial solid media described above follow incubation under anaerobic conditions for 2-12 days. 

Side effects typically effect the CNS, appearing within 2 weeks of therapy and disappearing after drug withdrawal. They include somnolence, headache, tremor, dysarthria, vertigo, confusion, nervousness, irritability, psychotic states, paranoid reactions, catatonic reactions, twitching, ankle clonus, hyperreflexia, visual disturbances, paresis, and seizures. Large doses or concomitant ingestion of alcohol increases the risk of seizures. Cycloserine is contraindicated in individuals with a history of epilepsy and should be used with caution in individuals with a history of depression. 

A brief report describes an enhancement of the effects of alcohol in 2 patients taking cycloserine. The clinical significance of this case report is unclear. However, the manufacturers of cycloserine state that it is incompatible with alcohol because of an increased risk of epileptic episodes, and contraindicate its use in alcohol abuse. ... 

---