Cyclooxygenase-2 genes

Nogawa, S., Zhang, F., Ross, M. E. and Iadecola, C. Cyclooxygenase-2 gene expression in neurons contributes to ischemic brain damage. /. Neurosci. 17 2746-2755,1997. 

Moon, Y. and Pestka J.J. Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases. Toxicol. Sci. 69, 373, 2002. 

Dixon, D. A. et al. Post-transcriptional control of cyclooxygenase-2 gene expression. The role of the 3 -untranslated region. J. Biol. Chem. 275, 11750, 2000. 

Kiritoshi S, Nishikawa T, Sonoda K, Kukidome D, Senokuchi T, Matsuo T, Matsumura T, Tokunaga H, Brownlee M, Araki E (2003) Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells potential role in diabetic nephropathy. Diabetes 52 2570-2577. 

Eberhart CE, Coffey RJ, Radhika A, et al. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 1994 107 1183-1188. 

Atsumi T, Murakami Y, Shibuya K, Tonosaki K, Fujisawa S. 2005b. Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression, by curcumin and its analog, alpha-diisoeugenol. Anticancer Res 25 4029—4036. 

Lukiw WJ, Bazan NG (1998) Strong nuclear factor-kappaB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer s disease superior temporal lobe neocortex. J Neurosci Res 153 583-592... 

Subbaramaiah K, Altorki N, Chung WJ, Mestre JR, Sampat A, Dannenberg AJ. Inhibition of cyclooxygenase-2 gene expression by p53. J Biol Chem. 274 (1999) 10911-10915. 

Yamamoto, K., Wang, J., Yamamoto, S., and Tobe, H., Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoid, FEBS Lett, 2000 Jan 14 465(2-3) 103-106. 

Cianchi, F., Cortesini, C., Bechi, P., Fantappie, O., Messerini, L., Vannacci, A., Sardi, L, Baroni, G., Boddi, V., Mazzanti, R., and Masini, E. (2001) Up-Regulation of Cyclooxygenase 2 Gene Expression Correlates with Tumor Angiogenesis in Human Colorectal Cancer, Gastroenterology 121, 1339-1347. 

Miller, C., Zhang, M., He, Y, Zhao, J., Pelletier, J.P., Martel-Pelletier, J., and Di Battista, J.A. (1998) Transcriptional Induction of Cyclooxygenase-2 Gene by Okadaic Acid Inhibition of Phosphatase Activity in Human Chondrocytes Co-Stimulation of AP-1 and CRE Nuclear Binding Proteins, J. Cell. Biochem. 69, 392 13. 

Eberhart, C ., Coffey, RJ., Radhika, A., GiardieUo, EM., Eer-renbach, S., and DuBois, RJ4. (1994) Up-Regulation of Cyclooxygenase 2 Gene Expression in Human Colorectal Adenomas and Adenocarcinomas, Gayiroenteralogy 107,1183-1188. 

Ballou, L.R., Chao, C.P., Holness, M.A., Barker, S.C., and Raghow, R., 1992, Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide. J.Biol.Chem. 267 20044-20050. 

Brueggemeier RW, Quinn AL, Parrett ML, et al. Correlation of aromatase and cyclooxygenase gene expression in human breast cancer specimens. Cancer Lett 1999 140 27-35. 

Soriani M, Rice-Evans CA, Tyrrell RM. Modulation of the UVA activation of haem oxygenase, coUagenase and cyclooxygenase gene expression hy epigallocatechin in human skin cells. FEES Lett 1998 439 253-257. 

Kujubu DA, Herschman HR. Dexamethasone inhibits mitogen induction of the TISIO prostaglandin synthase/cyclooxygenase gene. J Biol Chem 1992 267 7991-7994. 

Genes involved in the uptake and degradation of tocopherols - Genes implicated with lipid uptake and. Mi / °f J - Protein kinase C (PKC) - Cyclooxygenase - 5-Lipoxygenase - Cytokine release (IL-1P)... 

Additional genes and protein receptors are believed to be important in colorectal tumorigenesis. Cyclooxygenase 2 (COX-2), which is induced in colorectal cancer cells, influences apoptosis and other cellular functions in colon cells, and overexpression of the epidermal growth factor receptor (EGFR), a transmembrane glycoprotein involved... 

Exposure to trichothecenes at levels that partially inhibit translation upregulates expression of many inflammatory and immune-related genes including macrophage, Thl and Th2 cytokines as well as chemokines, cyclooxygenase 2 and inducible nitric oxide synthase.1518 Contrastingly, suppressive effects of trichothecenes on leukocyte function are intimately linked with the induction of apoptosis as has been demonstrated in macrophages, T cells and B cells both in vivo and in vitro.19-20... 

Liu Q, Chen ZQ, Bobustuc GC, et al. Local gene transduction of cyclooxygenase-1 increases blood flow in injured atherosclerotic rabbit arteries. Circulation. Apr 12 2005 111(14) 1833-1840. 

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