Cyclodextrins supramolecular complexes

Higashi, T., Nishimura, K., Yoshimatsu, A., Dceda, H., Arima, K., Motoyama, K., Hirayama, R, Uekama, K., and Arima, H. (2009). Preparation of four types coenzyme QlO/gamma-cyclodextrin supramolecular complexes and comparison of their pharmaceutical properties. Chemical and Pharmaceutical Bulletin, 57, 965-970. 

Bonchio, M., Carofiglio, T., Carraro, M., et al. (2002). Efficient Sensitized Photooxygenation in Water by a Porphyrin-Cyclodextrin Supramolecular Complex, Org. Lett., 4, pp. 4635-4637. 

This short compilation of the recent literature results convincingly demonstrates the usefulness of water-soluble supramolecular complexing agents in biphasic aqueous organometalHc catalysis. Due to their availability, cyclodextrins play a major role in this field. Thinking of the relatively low price of these chemicals (a few per kg in 1998 [2]) their use on a larger scale can also be envisaged in fine chemicals production. 

Ofloxacin was characterized by UV, vibrational, IR spectroscopies, 1H-, 13C-NMR spectrometry, X-ray powder diffraction pattern, single crystal X-ray diffraction, and mass spectrometry (09MI3). Levofloxacin formed a supramolecular complex with p-cyclodextrin at a molar ratio of 1 1, which was characterized by using UV, fluorescent spectra, DSC, and X-ray diffraction (07MI68). 

Chechik V, Ionita G (2006) Supramolecular complexes of spin-labelled cyclodextrins. Org Biomol Chem 4 3505-3510... 

Cyclodextrins as supramolecular complexing agents in electroanalytical chemistry (review, 1995-2001) ... 

Furuta T, Yoshii H, Miyamoto A, Yasunishi A, Hirano H. 1993. Effects of water of inclusion complexes of D-limonene and cyclodextrins. Supramolecular Chemistry 1 321-325. 

Supramolecular Complexes of Polymers Bearing Cyclodextrin Moieties with Guest Molecules... 

D. Krois, U. H. Brinker, Induced circular dichroism and UV-vis absorption spectroscopy of cyclodextrin inclusion complexes structural elucidation of supramolecular aziadamantane (spiro[adamantane-2,3 -diazirine]), /. Am. Chem. Soc., 1998, 120, 11627-11632. 

Callari F, Petraia S, Sortino S. 2006. Efighly photoresponsive monolayer protected gold clusters by self assembly of a cyclodextrin azobenzene derived supramolecular complex. Chem Commun 1009 1011. 

Zheng PJ, Wang C, Hu X, Tam KC, Li L. 2005. Supramolecular complexes of azocellulose and alpha cyclodextrin isothermal titration calorimetric and spectroscopic studies. Macromolecules 38(7) 2859 2864. 

C. Gamero, A.K. Chattah, M. Longhi, Improving farosemide polymorphs properties through supramolecular complexes of p-cyclodextrin, J. Pharm. Biomed. Anal. 95 (2014) 139-145. 

A.K. Chattah, K.H. Mrone, L.Y. Pfund, A. Ramamoorthy, M.R. Longhi, C. Gamero, Insights into novel supramolecular complexes of two sohd forms of Norfloxacin and p-Cyclodextrin, J. Pharm. Sci. 102 (2013) 3717—3724. 

Supramolecular structures such as rotaxanes occasionally play important roles in enzymatic activities. For example, DNA polymerases contain sliding clamps in which the ring-shaped protein assemblies form supramolecular complexes. The ring-shaped clamp peptides of DNA (or RNA) polymerases participate in binding two polynucleotide chains for replication. ° The clamps have no active sites and replication of polynucleotides is difficult without clamps. Similarly, cyclodextrins (CDs) and other host molecules are ring-shaped host molecules that include various guests to form supramolecular complexes such as rotaxanes. ... 

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