Cyclic ADP ribose

Eisner For a spark, most of it isn t lost, but from a wave which will see the surface membrane, you will lose a lot. This then comes back to the question of cyclic ADP ribose, FK506 and so on that may potentiate Ca2+ release from the SR, but in the presence of these things you will end up with less Ca2+ in the SR. 

Wilson HL, Dipp M, Thomas JM, Lad C, Galione A, Evans AM 2001 ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase act as a redox sensor. A primary role for cyclic ADP-ribose in hypoxic pulmonary vasoconstriction. J Biol Chem 276 11180-11188... 

In some cell types (including cardiac muscle cells, pancreatic cells), another second messenger", the cyclic ADP-ribose (Fig. 6.8), is involved in opening the ryanodin receptors (Lee et al., 1994). The cADP-ribose is formed from NAD by an enzymatic pathway with the help of an ADP-ribosyl cyclase. 

Lee, H.C., Galione, A. und Walseth, T.F. Cyclic ADP-ribose metabolism and calcium mobilizing function (1994) Vitam. Horm. 48,199-257... 

Cyclic ADP-ribose (cADPR) and 2 -P-cADPR Chapter 15, Section E... 

Several uncertainties have complicated our understanding of the role of Ca2+ in signaling. What is the source of Ca2+ How much of it enters cells from the outside and how much is released from internal stores Where are the internal stores What other kinds of ion channels are present and what second messengers regulate them The sarcoplasmic reticulum of skeletal muscle and also membranes in many other cells contain ryanodine receptors as well as InsP3 receptors.282 293 Both of these receptors have similar structures and contain Ca2+ channels. However, the ryanodine receptors are activated by cyclic ADP ribose (cADPR),294/295 which was first discovered as a compound inducing the release of Ca2+ in sea urchin eggs.296 The 2-phospho derivative of cADPR may also have a similar function.297... 

Second Law of Thermodynamics 284285 Second messengers 553 calcium ions 555 cyclic ADP-ribose 555 cyclic AMP 555 cyclic GMP 555... 

Long-term depression (LTD) is the loss of synaptic strength after passage of an impulse. There is evidence that during brain activity, including that in the hippocampus, both LTP and LTD are essential.10351036 LTD may depend upon cyclic ADP-ribose (p. 564).1037 LTD, like LTP, may also spread via retrograde signaling.1038... 

Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH. 1995. ATP-dependent accumulation and inositol trisphosphate- or cyclic ADP-ribose-mediated release of Ca2+ from the nuclear envelope. Cell 80 439-444. 

Galione A, White A, Willmott N et al (1993) cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis. Nature 365 456-9... 

Lawrence DM, Major EO (2002) HIV-1 and the brain connections between HIV-l-associated dementia, neuropathology and neuroimmunology. Microbes Infect 4 301-8 Lee HC (2001) Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers. Annu Rev Pharmacol Toxicol 41 317—45... 

Galione A (1994) Cyclic ADP-ribose, the ADP-ribosyl cyclase pathway and calcium signalling. Mol Cell Endocrinol 98 125-31... 

Reyes M, Stanton PK (1996) Induction of hippocampal long-term depression requires release of Ca2+ from separate presynaptic and postsynaptic intracellular stores. J Neurosci 16 5951-60 Reyes-Harde M, Empson R, Potter BV, Galione A, Stanton PK (1999a) Evidence of a role for cyclic ADP-ribose in long-term synaptic depression in hippocampus. Proc Natl Acad Sci USA 96 4061-6... 

Partida-Sanchez, S., Cockayne, D. A., Monard, S., Jacobson, E. L., Oppenheimer, N., Garvy, B., Kusser, K., Goodrich, S., Howard, M., Harmsen, A., Randall, T. D., and Lund, F. E. (2001). Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo. Nat. Med. 7, 1209-1216. 

Durner, J., Wendehenne, D. and Klessig, D.F., 1998, Defense gene induction in tobacco by nitric oxide, cyclic GMP, and cyclic ADP-ribose. Proc. Natl. Acad. Sci. USA 95 10328-10333. 

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