Cutaneous reactions symptoms

Adverse effects. Fatigue, orthostatic hypotension, extrapyramidal Parkin-son-like symptoms (p. 88), cutaneous reactions, hepatic damage, immune-hemolytic anemia... 

Cutaneous reactions are uncommon with quinidine they are more commonly associated with the optical isomer, quinine. Drug fever either occuring alone or in combination with other symptoms is a more frequent manifestation of hypersensitivity than the cutaneous signs (Sturnick 1942), but even quinidine fever is very unusual (Abrams 1973). 

Allergy a hypersensitivity of the immune apparatus s pathological immune reaction induced either by antibodies (immediate hypersensitivity) or by lymphoid cells (delayed type A.). Unlike the delayed type, immediate hypersensitivity can be passively transmitted in the serum. Symptoms of immediate hy-peisensitivity begin shortly after contact and decay rapidly, but delayed type symptoms do not attain a maximum for 24-48 hours then decline slowly over days or weeks Examples of immediate type A. are anaphylaxis the Arthus reaction and serum sickness. The best known A., anaphylaxia, can occur as a local (cutaneous) reaction (e.g. a rash with blisters) or as a systemic reaction (anaphylactic shock). Asthma, hay fever and nettle rashes are also examples of local anaphylactic reactions which are induced by reagins (see Immunoglobulins IgE). Only primates can be sensitized by injection with human reagins. An example of delayed type A. is the tuberculin reaction, which is based on a cellular immune response. 

Allergies to macrolide antibiotics are said to occur with an incidence of 0.4-3 %. Apart from the very occasional case report of anaphylaxis, the most commonly seen symptoms include urticaria, often generalized, angio-edema, pruritus, asthma, tachycardia, and delayed cutaneous reactions presenting as maculopapular exanthema. 

Adverse reactions to dextran 1 were investigated in trials involving over 70,000 patients. The following reactions and incidences were recorded cutaneous reactions 0.016 % moderate hypotension 0.014 % severe hypotension 0.001 % bradycardia and moderate hypotension 0.013 % bradycardia and severe hypotension 0.001 % bradycardia alone 0.004 % and mild symptoms (nausea, pallor, shivering) 0.011 %. 

Severe bullous cutaneous reactions (SJS, TEN) Oxicams, phenylbutazone, oxyphenylbutazone, some COX-2 inhibitors, diflunisal Reactions rare Symptoms may occur up to 8 weeks after drug administration... 

Adverse reactions to IFNa include flu -like symptoms, a wide range of cutaneous reactions, autoimmune thrombocytopenia, and hemolytic anemia. 

Table 13.1). Other more severe symptoms sometimes reported are bronchospasm, chest pain, seizures, and systemic anaphylaxis that may be life-threatening. Reactions to oxaliplatin are similar to those seen in response to cisplatin and carboplatin, but the responses to oxali-plafin tend to be more heterogeneous and unpredictable with fewer cutaneous reactions idiosyncratic reactions like cytokine release syndrome and pulmonary fibrosis fewer reports of severe anaphylaxis and a higher incidence of respiratory symptoms including laryngeal spasms and hypoxemia A few cases of type II thrombocytopenia and type HI immune complex-mediated urticaria, joint pain, and proteinuria associated with oxaliplatin have also been reported. 

Gastrointestinal symptoms, thrombocytopenia, peripheral neuropathy, and neuropathic pain are the most common side effects of bortezomib and adverse cutaneous reactions to the dmg are... 

The relationship between cutaneous and systemic reactions in diseases such as drug reaction with eosinophilia and systemic symptoms (DRESS or hypersensitivity syndrome) and why the same drug produces both reactions in some patients but only cutaneous reactions in others. 

Immunologic Hypersensitivity reactions to docetaxel occur in about 20-30% of cases, usually within a few minutes of starting an infusion [142 ]. They most commonly occur during the first or second cycle of treatment. The symptoms may be minor, such as flushing or localized cutaneous reactions, or more severe, such as severe hypotension, bronchospasm, or generalized rash/ erythema. Patients who develop severe hypersensitivity reactions should not be rechallenged with docetaxel [111 ]. 

Initial features are mostly pulselessness, difficulty in ventilation, desaturation, and a decreased end-tidal CO2. Cutaneous symptoms are observed in 66-70% of patients in case of IgE-mediated reactions but in more than 90% in non-IgE-mediated reactions. On the contrary, cardiovascular collapse and bronchospasm are more frequent in IgE-dependent reactions (table 2). Severe anaphylaxis may be a primary cardiac arrest [9]. 

Many different symptoms can occur during IgE-mediated food allergies including cutaneous, gastrointestinal, respiratory, and sometimes cardiovascular symptoms (Table 4.3). Reactions can sometimes be fairly mild, but severe and life-threatening reactions involving symptoms such as lar)mgeal edema, asthma, and anaphylactic shock can occur on occasion. 

Allergenic activity. Fiber of the dried seed, administered orally to female adults, was active. Total serum immunoglobulin (Ig) E was elevated in a 40-year-old woman with allergic cutaneous and respiratory symptoms associated with chronic psyllium ingestion . Dried seedcoat, administered orally to adults, was active. A 60-year-old female suffered an anaphylactic reaction after ingestion of a psyllium-containing cereal f Skin prick result from psyllium powder and specific IgE antibodies were positive in a 31-year-old atopic woman who... 

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