Current detection technologies

Remote Field Eddy Current (RFEC) technology is a variation of the conventional eddy-current method, developed for detecting flaws at any point in the walls of (particularly) ferromagnetic (Fe) tubes and pipes from the inside diameter. 

Their R D activities are oriented to deepen and broaden the current proprietary technology portfolio that they use in offering their services but also to use their own platform in drug discovery, diagnostics and detection and prevention of drug effects. 

Buehler, C., Stoeckli, K. and Auer, M. (2001). The integration of single molecule detection technologies into miniturized drug screening Current status and future perspectives. In New Trends in Fluorescence Spectroscopy (Valeur, B. and Brochon, J. C., eds.). Springer, Berlin, pp. 331-79. 

Eggeling, C., Brand, L., Ullmann, D., and Jager, S., Highly sensitive fluorescence detection technology currently available for HTS, Drug Discov. Today, 8, 632, 2003. 

There are a variety of detection technologies currently available and others under development. 

We plan to take advantage of ligand-induced enhancement of dipicolinate binding affinity to improve current bacterial spore detection technologies in two ways. The first involves appending terbium(macrocycle) complexes to solid polymer substrates to improve microscopy-based endospore assays. In a second method, we will bind lanthanide complexes to silica to concentrate dipicolinate from very dilute samples on colmnns. 

As biotechnology research continues to push the limits of our current instrumentation and assays, there arises a need for new technologies and products to come to the forefront and allow the next generation of experiments to continue. Near-IR MEF using CCA is a tool that should complement current fluorescence technology, allowing for greater sensitivity and reduced detection limits. 

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