Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Curator sources

Another major source are the amino acid sequences direcdy derived from protein sequencing. Thousands of such sequences have been detected by the SWISS-PROT curators in publications (or have been directly submitted by researchers to SWISS-PROT) and entered into the database. Protein sequences detected by the NCBI journal scan have also been included. For some proteins the Brookhaven Protein Data Bank (PDB) (Abola et al., 1996) is the only source for the sequence information. The PDB entries are checked regularly, and new SWISS-PROT entries were created whenever necessary. [Pg.66]

Preservation of cultural goods is an important and rewarding task of modern societies. They are a vital source of inspiration and reflect the culture and history of the past and present. This valuable asset is the basis for future cultures and therefore, is one of the main legacies to be passed on to future generations. For this purpose, conservators, curators, art historians, and scientists combine their efforts, making it now a pluridisciplinary activity. [Pg.1]

Databases are electronic filing cabinets that serve as a convenient and efficient means of storing vast amounts of information. An important distinction exists between primary (archival) and secondary (curated) databases. The primary databases represent experimental results with some interpretation. Their record is the sequence as it was experimentally derived. The DNA, RNA, or protein sequences are the items to be computed on and worked with as the valuable components of the primary databases. The secondary databases contain the fruits of analyses of the sequences in the primary sources such as patterns, motifs, functional sites, and so on. Most biochemical and/or molecular biology databases in the public domains are flat-file databases. Each entry of a database is given a unique identifier (i.e., an entry name and/or accession number) so that it can be retrieved uniformly by the combination of the database name and the identifier. [Pg.48]

C. A. Cooper, H. J. Joshi, M. J. Harrison, M. R. Wilkins, and N. H. Packer, GlycoSuiteDB A curated relational database of glycoprotein glycan structures and their biological sources. 2003 update, Nucleic Acids Res., 31 (2003) 511-513. [Pg.266]

Data curation involves capturing of data from journals and patents to be entered into an ISIS-base template designed for a specific database. The data resources here were journal articles, patents, publicly available resources, conference abstracts, and industry brochures. When the data resource contains individually specified or characterized compounds, then it would be curated based on three criteria, quantitative activity data, qualitative activity data, and data containing no activity information. Curation of quantitative activity data was restricted to the number of scaffolds and kind of activity. When the activity was distinct to the compounds all the compounds reported in a data source were curated, while it was restricted to a maximum of 500 compounds covering all the scaffolds in the data source when a range of activities was reported. [Pg.161]

The informatics process requires the integration and analysis of datasets in the public domain as well as from proprietary data sources that represent the intellectual property of the research organization. Public flat-file biology data are often curated and delivered from a number of public ftp sites. This information is released periodically, and any private storage of this information must be kept up to date with the public data as they are released. In addition, these data may be available in a variety of physical formats, such as flat file, Extensible Markup Language (XML), and relational. Software systems must support the ability to keep proprietary information physically separate to facilitate both the periodic update of public data and the integrity and security of private intellectual property. [Pg.412]

A much more ambitious database that builds on the IUBMB classification is BRENDA, maintained by the Institute of Biochemistry at the University of Cologne. In addition to the data provided by the ENZYME database, the BRENDA curators have extracted a large body of information from the enzyme literature and incorporated it into the database. The database format strives to be readable by both humans and machines. The categories of data stored in BRENDA comprise the EC-number, systematic and recommended names, synonyms, CAS-registry numbers, the reaction catalyzed, a list of known substrates and products, the natural substrates, specific activities, KM values, pH and temperature optima, cofactor and ion requirements, inhibitors, sources, localization, purification schemes, molecular weight, subunit structure, posttranslational modifications, enzyme stability, database links, and last but not least an extensive bibliography. Currently, BRENDA holds entries for approximately 3500 different enzymes. [Pg.152]

All the non-archival sources cited here, except the private communications and the online document, are available at the Science Museum Library. The unpublished Annual Reports of the Science Museum and much of the published Science Museum material are kept in the semi-rare book room. In addition to these sources, I also had access to the chemistry curator s collection of gallery photographs and a set of labels with floor plans for the 1977 Gallery. [Pg.325]

Rome in the first century of the Christian era had a remarkable water supply system administered by a body of officials comparable to the modern Water Board. The chief officer was the Curator Aquarum the supply of water was taken from nine different sources, including springs and lakes from io to 60 miles from the city supplies suitable for potable purposes were kept apart from less pure waters which were used for public fountains, baths and sanitation. Each length of pipe bore raised inscriptions formed by impressions in the sand bed in which the lead sheet was cast. The inscriptions indicated the person authorised to receive the water. [Pg.189]

As indicated above, the focus of this review is on curated databases containing chemical structure and biological activity taken from literature sources. We nevertheless recognise the existence of a growing number of databases that also contain such structure and activity data but which do not fall within our primary scope. Of particular relevance here are databases that contain "raw" screening data, often generated by publicly-funded research initiatives. Two prominent examples are Pubchem [4] and Chembank [5]. [Pg.204]


See other pages where Curator sources is mentioned: [Pg.155]    [Pg.62]    [Pg.236]    [Pg.64]    [Pg.66]    [Pg.87]    [Pg.316]    [Pg.356]    [Pg.69]    [Pg.33]    [Pg.37]    [Pg.87]    [Pg.70]    [Pg.236]    [Pg.239]    [Pg.172]    [Pg.180]    [Pg.95]    [Pg.25]    [Pg.297]    [Pg.745]    [Pg.52]    [Pg.743]    [Pg.38]    [Pg.283]    [Pg.168]    [Pg.36]    [Pg.37]    [Pg.37]    [Pg.29]    [Pg.103]    [Pg.169]    [Pg.148]    [Pg.265]    [Pg.777]    [Pg.347]    [Pg.204]    [Pg.210]    [Pg.213]    [Pg.365]    [Pg.136]   
See also in sourсe #XX -- [ Pg.293 , Pg.294 ]




SEARCH



Curated

Curation

Curators

© 2024 chempedia.info