CSF pressure

Infants (2 years of age or younger) - 4.2% solution for IV administration at a rate not to exceed 8 mEq/kg/day to guard against the possibility of producing hypernatremia, decreasing CSF pressure, and inducing intracranial hemorrhage. 

IR concentrated oral solution and tablets/suppositories - Respiratory insufficiency or depression severe CNS depression attack of bronchial asthma heart failure secondary to chronic lung disease cardiac arrhythmias increased intracranial or CSF pressure head injuries brain tumor acute alcoholism delirium tremens convulsive disorders after biliary tract surgery suspected surgical abdomen surgical anastomosis concomitantly with MAOIs or within 14 days of such treatment paralytic ileus. 

Head injury/increased intracranial presswre.Buprenorphine may elevate cerebrospinal fluid (CSF) pressure use with caution in head injury, intracranial lesions, and other states where CSF pressure may be increased. Buprenorphine can produce miosis and changes in consciousness levels that may interfere with patient evaluation. 

Halogenated hydrocarbon inhalation anesthetics may increase intracranial and CSF pressure. Cardiovascular effects include decreased myocardial contractility and stroke volume leading to lower arterial blood pressure. Malignant hyperthermia may occur with all inhalation anesthetics except nitrous oxide but has most commonly been seen with halothane. Especially halothane but probably also the other halogenated hydrocarbons have the potential for acute or chronic hepatic toxicity. Halothane has been almost completely replaced in modern anesthesia practice by newer agents. 

The disadvantages of spinal anesthesia are hypotension (ephedrine and methoxamine may prevent this), nausea and vomiting (avoided by thiopental), respiratory depression (treated by artificial respiration), and postoperative headache (treated by increasing the CSF pressure). 

Bono F, Lupo MR, Lavano A, Mangone L, Fera F, Pardatscher K, Quattrone A (2003) Cerebral MR venography of transverse sinuses in subjects with normal CSF pressure. Neurology 61 1267-1270... 

A 35-year-old woman with benign intracranial hypertension and high blood pressure was given amlodipine, with good control of her blood pressure (8). However, her headache worsened and she developed papilledema. The CSF pressure was 30 cm. Her symptoms disappeared shortly after amlodipine withdrawal. 

In some series, transient hearing loss after anesthesia with bupivacaine was found with intrathecal but not epidural administration (SEDA-13, 99) (SEDA-16, 129)(263). It has been suggested that the cause could be a reduction in CSF pressure transmitted through the cochlear aqueduct (264), a hypothesis that has been both supported and criticized (SEDA-16,129). Sensorineural hearing loss after spinal anesthesia with bupivacaine has been thought to be due to the entry of bupivacaine into the inner ear, resulting in a direct effect on its functional apparatus (265). 

CSF IgM-specific antibodies - present CSF pressure - increased CSF protein - increased CSF WBC - increased... 

The dynamics of urea transfer and cerebral pressure Hemodialysis patients sometimes experience headache, nausea, confusion, and even convulsions during treatment. These symptoms have been referred to as the disequilibrium syndrome, and are believed to be related to an increase in cerebrospinal (CSF) pressure which occurs during rapid dialysis. It has been suggested that this is due to the removal of urea from the blood plasma at a rate greater than it can be removed from the CSF. 

Develop the dynamic response of the system and pay particular attention to the CSF pressure response for various removal rates, F. The CSF pressure can be expressed as... 

Moore and Sykes (1940) proposed that an elevation in CSF pressure might be the first physiological change specific to vitamin A deficiency. This has since been demonstrated to be a specific associated sign in pigs (Sorenson et al, 1954 Nelson et al., 1964), rats (Rokkones, 1955), chicks (Woollam and Millen,... 

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