Critical Remarks

Finally, it is important to emphasize that comparative evaluations of MOEAs for any application should be done based on results obtained by the algorithms using the same process model, rather than based on previously reported results (particularly when they are originated by different researchers). This is because of the potential (and unknown) differences in the process models used by different researchers and their effect on optimization results. 

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In addition to the contributors, quite a few persons participated in the project Acknowledgments are due to J P ChuppandR Hakes of Monsanto for critical remarks and to Angie Miller Wanda Ritter, and Janet LaPalometo for typing the manuscript... 

K. Grob and M. Biedeimann, Vapoi ising systems foi large volume injection oi on-line ti ansfer into gas cltromatography classification, critical remarks and suggestions , 7. Chromatogr. 750 11-23 (1996). 

Despite these critical remarks, this discussion may be summarized by saying that the participation of the nitrosoamine (3.7), of its conjugate O-acid (3.8), of the (Z)-or (i -diazohydroxide (3.9), and of their conjugate acids (3.10) in the system of Scheme 3-36 remains more or less conjectural, but at least the nitrosoamine (3.7) does appear to be reasonable well documented as an intermediate on the pathway to the diazonium ion. 

Financial support by the Committee for Scientific Research (KBN) grants 2 P303 058 07 (J.S.) and 3 T09A 038 08 (M. J.-H.) is acknowledged. The authors are very grateful to Dr. Piotr Zelenay for his valuable comments. We would also like to thank Professor John O M. Bockris for careful reading of the manuscript and many critical remarks. 

G. Wahba, University of Wisconsin, and F. Utreras, Universidad de Chile, have aided the author in obtaining original literature. In addition, G. Wahba has contributed critical remarks on the use of the method described in (13-15). 

For a complete picture, however, some critical remarks have to be added. For medium-sized molecules, the obviously successful combination of theoretical prediction and experimental verification rather should be considered as an individually tailored interplay, which is based on numerous assumptions i.e. so-called chemical intuition. Tobeginwith, any hypersurface design confined to a few selected coordinates will only cover the aspects introduced thereby. Even several independent cuts through the (3n-6) dimensional hyperspace cannot unravel the complexity of a molecule in a specific molecular state. And although semiempirical methods - especially MNDO (10)- are not only fast but to quite an extent also reliable, their numerical accuracy should not be overstressed. Thus semiempirical hypersurfaces might better be considered as supplying trends in essential features, which can be compared to and correlated with measurement data to add the numerical accuracy, and, in return, to test and to substantiate all underlying assumptions. 

A critical remark that should be made in this context is that the authors merely took as independent variables the treatments applied at the time of first hospitalization, neglecting other factors that had arisen in subsequent years. If the patients really were schizophrenics, it is almost certain that the majority of them would have received further treatment that contrary to the original experimental plan could no longer be introduced in the sense of a controlled trial. The results after 4 and 5 years must be regarded rather cautiously for this reason. 

Professor Sokolov s question whether I challenge mathematics or wave-mechanics is significant, since it only emphasizes my point. My critical remarks rather represent their defence against unjustified applications. 

I am indebted to B.R.A. Nijboer, H. Falk, and J. Groeneveld for critical remarks, to the students who reported a number of misprints, and to Leonie J.M. Silkens for indefatigable typing and retyping. 

The authors would like to thank Dr. J. Hempel and Dr. A. A. Cantu for their critical remarks. 

Another critical remark concerns the spherical shape assumed for both micro- and macroparticles in the MGM. Often this assumption should be qualified as a rough simplification, for examples for agglomerates, see Fig. 5.4-8. However "real-morphology" models are hardly available, and non-symmetric growth is difficult to compute. 

The above critical remarks do not diminish the enormous success in the development of oxidation reactions that seem close to impossible within the framework of homogeneous chemistry. The most successful process is the one-step reaction of butane to maleic anhydride (MA) ... 

Critical Remarks Regarding Structure-based Pharmacophore Models... 

First, a few critical remarks on three topics of eyewitness statements relating to homicidal mass gassings should be made at this point. 

Reserve critical remarks until after some of the positives have been accentuated. 

The author gratefully acknowledges Mr. Stefan Mogl for proofreading the manuscript, for his editorial comments, and his valuable advice and critical remarks. 

At this point, some critical remarks are in order. The tables are short, and many important materials are not listed. Absent are all the naturals, and 20°C is a rather arbitrarily selected temperature at the skin surface 30°C would be more appropriate. What is more, compared to such readings as "it persists on the blotter for more than two weeks" which has some recognizable meaning, the values of vapor pressure, such as 0.00008 micron, are very abstract. Let us briefly address these objections. 

Abstract. A number of observations and critical remarks were made dealing with perspectives of the metallic materials (both classical alloys and quasi-crystals) and nano-sized carbon materials as reversible accumulators of hydrogen. 

The next section (Sect. 2) is devoted to a lengthy discussion of the molecular hypothesis from the point of view of quantum field theory, and this provides the basis for the subsequent discussion of optical activity. Having used linear response theory to establish the equations for optical activity (Sect. 3), we pause to discuss the properties of the wavefunctions of optically active isomers in relation to the space inversion operator (Sect. 4), before indicating how the general optical activity equations can be related to the usual Rosenfeld equation for the optical rotation in a chiral molecule. Finally (Sect. 5), there are critical remarks about what can currently be said in the microscopic quantum-mechanical theory of optical activity based on some approximate models of the field theory. 

In spite of some critical remarks , the hypervalent model is successfully used in interpreting the results of physicochemical investigations " " . For discussion on using the term hypercoordinate instead of hypervalent , see Reference 37. 

In spite of some critical remarks the hypervalent model is successfully used for... 

As has been mentioned above, the methods of statistical mechanics used by Flory for the theoretical calculation of the change in the free energy of mixing rigid rods and a solvent are based on a number of assumptions. Nevertheless, as can be seen from a comparison of theoretical results with experimental data, the main conclusions are qualitatively in coincidence. Critical remarks made in publications after the works of Flory and Onsager mainly dealt with some details... 

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