Cream progesterone

Topical Cream-. 5% (First Progesterone MC5), 10% (First Progesterone MClO). 

The development of a simple fast-scan polarographic method for the determination of the A4-3-ketosteroid flurandrenolone in pharmaceutical preparations has been reported [134]. The polarographic peak due to the reduction of the carbon-fluorine bond is measured in ointments and creams to determine concentrations as low as 0.01 % w/w. Pulse polarographic procedures have been described for progesterones [135], A4-3-ketosteroids [136], hydrocortisone [137], and flucytosine [138] in pharmaceutical preparations. Recent studies have illus-... 

Therapeutically used types of estrogens and prog-estins are listed in Tables 30-4 and 30-5. Both types of hormones can be administered in their natural form (estradiol and progesterone), and several synthetic derivatives of each type are also available. Most of the drugs listed in Tables 30-4 and 30-5 are available as oral preparations, and many conditions can be conveniently treated by oral administration. These hormones may also be administered transdermally via patches, creams, or gels the transdermal route may offer certain advantages, such as decreased side effects and liver problems.86,130 Certain preparations can be... 

Probably the most widely used hormone preparations in the world are those used in healthy women who are not suffering from a disease. These are, of course, birth control pills, which usually contain derivatives of estrogen and progesterone. While they can be used in certain gynecologic disorders with efficacy, the vast majority of prescriptions are written to prevent pregnancy. Their development introduced a new era in society a virtually 100 percent effectiveness, replacing IUDs (intrauterine devices), condoms, creams, jellies, and diaphragms. 

Kimzey, L. Gumowski, J. Merriam, G. Grimes, G., Jr. Nelson, L., Jr. Absorption of micronized progesterone from a nonliquefying vaginal cream. Fertil. Steril. 1991, 56, 995-996. 

An uncontrolled study in 2002 by Lucks examined the effects of 3-month dermal application of V. agnus-castus essential oil (oil distilled at some point in the shrubs development of the fruit but while some leaves were still on the plant) on menopausal and perimenopausal symptoms. A 1.5% solution of the essential oil was incorporated in a bland cream or lotion and applied once a day, 5 to 7 days/week, for 3 months. Descriptive outcome measures were self-report via a survey of symptomatic relief (major, moderate, mild, none, worse) and side effects. A total of 33% of women reported major improvement in symptoms, with the most often area of improvement being hot flashes/ night sweats. Both improvement and worsening occurred in the areas of emotions and menstruation flow. Subjects who were also on progesterone supplementation reported breakthrough bleeding (7). 

Women often seek relief for premenstrual and perimenopausal symptoms from alternative or nontraditional treatments without consulting their health care providers. Herbal therapies, phytoestrogens, progesterone creams, megavitamins, folk remedies, and homeopathy are marketed to women without scientific evidence of efficacy or safety. Clinicians should ask women if they use alternative/ complementary therapies and become familiar with the products (e.g., mechanism of action, efficacy, dosing, side effects, monitoring, and drug-herb and herb-herb interactions). 

Gambrell RD. Progesterone skin cream and measurements of absorption. Menopause 2003 10 1-3. 

Preparation of capsules, creams, suppositories or eye drops with steroids such as progesterone, testosterone, estradiol, and estriol. 

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