Cotransporters sodium-glucose

SGLT2 is a low-affinity, high capacity sodium-glucose cotransporter located in the early proximal convoluted tubule SI segment. SGLT2 comprises 13... [Pg.550]

Sodium/glucose cotransporter (rabbit intestinal brush borders)1641 Stearylcoenzyme A desaturase (rat liver microsomal)[651 Subtilopeptidase amylosacchariticus[661 Succinate dehydrogenase (mitochondrial)1671... [Pg.167]

Cramer, S. C., et al. Colocalization of GLUT2 glucose transporter, sodium/ glucose cotransporter, and gamma-glutamyl transpeptidase in rat kidney with double-peroxidase immunocyto-chemistry. Diabetes 1992, 43, 766—770. [Pg.281]

Wells, R. G., et al. Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter. Am. J. Physiol. 1992, 263, F459-F465. [Pg.281]

Serial transfer, 172,173 Sequence space, 150 Short-day plants, 225 Sodium-glucose cotransport, 261-263 Sodium pump, 258 et seq. [Pg.304]

About 70% of the filtered Na and K is resorbed in the proximal tubule. Sodium is cotransported with glucose and the amino adds, resulting in the resorption of over 99% of these nutrients. Cotransport of Na with bicarbonate results in resorption of 80 to 90% of the filtered bicarbonate. The uptake of these nutrients at the apical membrane occurs by Na mino acid and Na-glucose cotransport systems. One of two sodium ions are cotransported with each glucose. Seven Na-amino acid cotransport systems have been found in the renal tubule. These include systems specific for acidic amino acids, basic amino acids, glycine, neutral amino acids, cysteine, and cystine. One or more sodium ions are cotransported with each amino acid. [Pg.716]

Cotransporters use the sodium or hydrogen ion gradient to drive transport of a substrate. Many cotransporters have been described, cloned, sequenced, and expressed. The sodium-glucose cotransporter just described is one of these. [Pg.27]

Other cotransporters facilitate the transport of other sugars, osmolytes, and amino acids. In humans, a disorder of intestinal glucose and galactose absorption is due to a defective sodium-glucose transporter. [Pg.27]

SLC5 (7) Sodium/glucose cotransporter, iodide SGLT, SMVT, reproductive organs Intestine, kidney, brain,... [Pg.268]

Figure 10.27 A schematic model for the sodium-glucose cotransport (symport) system. [Pg.1289]

There appears to be no control of the absorption of dietary sodium, which essentially is totally absorbed, provided that glucose is available for transport processes. Sodium absorption takes place by several mechanisms, of which electroneutral cotransport subsystems account for about 20%, diffusion possibly for up to 50%, and other transport processes for the remainder. Sodium-glucose and sodium-amino acid cotransporters exist in the apical membranes of erythrocytes and mediate sodium uptake coupled to glucose or amino acid uptake. Thus, the absorption of glucose and some amino acids is dependent on sodium uptake. [Pg.505]

Tahrani AA, Barnett AH. Dapaglifloxin a sodium glucose cotransporter 2 inhibitor in development for type 2 diabetes. Diabetes Ther 2010 1 45-56. [Pg.701]

Ghosh RK, Bandyopadhyay D, Hajra A, Biswas M, Gupta A (2016) Cmdiovascular outcomes of sodium-glucose cotransporter 2 inhibitors a comprehensive review of cliniceil tmd preclinical studies. Int J Cardiol 212 29-36... [Pg.272]

Schwartz SS, Ahmed I (2016) Sodium-glucose cotransporter-2 inhibitors an evidence-based practice approach to their use in the natural history of type 2 diabetes. Curr Med Res Opin... [Pg.274]

Wu JH, Foote C, Blomster J et al (2016) Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 4 411 19 [Epub ahead of print]... [Pg.277]

Yamaguchi K, Kato M, Suzuki M, et al. Pharmacokinetic and pharmacodynamic modeling of the effect of a sodium—glucose cotransporter inhibitor, phlorizin, on renal glucose transport in rats. Drug Metab Dispos. 2011 39(10) 1801—1807. [Pg.194]

Swift, RG.F. and Schaub, J. (2001) Mutations in SGLT2, the gene for a renal sodium/ glucose cotransporter, in patients with renal glycosuria. Submitted for publication. [Pg.367]

Sodium-dependent glucose cotransporters (SGLT) are located on small-intestine and kidney brush-border membranes. SGLT1, SGLT2, and SGLT3 are... [Pg.550]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...