Transpeptidase, gamma-glutamyl

Cramer, S. C., et al. Colocalization of GLUT2 glucose transporter, sodium/ glucose cotransporter, and gamma-glutamyl transpeptidase in rat kidney with double-peroxidase immunocyto-chemistry. Diabetes 1992, 43, 766—770. 

Volume 401. Glutathione Transferases and Gamma Glutamyl Transpeptidases Edited by Helmut Sies and Lester Packer... 

Yasuda K, Yamashita S, Aiso S, et al. Immunohistochemical study of gamma-glutamyl transpeptidase with monocloncal antibodies. I. Preparation and characterization of monoclonal antibodies to gamma-glutamyl transpeptidase. Acta Histochem. Cytochem. 1986 19 589-592. 

Rat Sprague- Dawley 10 wk ad lib (F) Hepatic 500 M (mild fatty change, increased gamma glutamyl-transpeptidase + foci) DeAngelo et al. 1986 X m T T m 3 to... 

Carter JH, Richmond RE, Carter HW, et al. 1992. Quantitative image cytometry of hepatocytes expressing gamma-glutamyl transpeptidase and glutathione S-transferase in diethylnitrosamine-initiated rats treated with phenobarbital and/or phthalate esters. J Histochem Cytochem 40 1105-1115. 

Hepatic effects Prescribe with care in patients with current evidence or history of abnormal liver function indicated by significant abnormalities in serum transaminase, bilirubin, and gamma-glutamyl transpeptidase levels. 

NT263 Anand, C. V., U. Anand, and R. Agarwal. Anti-oxidant enzymes, gamma-glutamyl transpeptidase and lipid peroxidation in kidney of rats exposed to cigarette smoke. Indian J Exp Biol 1996 34(5) 486-488. 

Baumrucker, C. R. 1979. Gamma-glutamyl transpeptidase of bovine milk membranes distribution and characterization. J. Dairy Sci. 62, 253-258. 

Cholestatic hepatitis developed in a 71-year-old man with nephrotic syndrome (2). Hepatic function was normal after several months of fluvastatin 20 mg/day. Some weeks after the dose was increased to 40 mg/day, his gamma-glutamyl transpeptidase activity rose from normal to 1818 IU/1, with negative serology for viruses. After normalization, re-introduction of fluvastatin 20 mg/day was not tolerated, but he did tolerate simvastatin 20 mg/day. 

Smith, T.K., et al. 1995. Different sites of acivicin binding and inactivation of gamma-glutamyl transpeptidases. Proc Natl Acad Sci USA 92 2360. 

Diaz-Flores, M., G. Duran-Reyes, and J.J. Hicks. 1994. Arrest of rat embryonic development by the inhibition of gamma-glutamyl transpeptidase. I. Intrauterine administration of L-serine-borate complex. Int J Fertil Menopausal Stud 39 234. 

Weber LW, Lebofsky M, Stahl BU, et al. 1992a. Comparative toxicity of four chlorinated dibenzo-p-dioxins (CDDs) and their mixture. Part II Structure-activity relationships with inhibition of hepatic phospholpyruvate carboxykinase, pyruvate carboxylase, and gamma-glutamyl transpeptidase activities. Arch Toxicol 66(7) 478-483. 

DeAngelo AB, Garrett CT, Queral AE, et al. 1985a. Phosphorylation of specific rat plasma membrane proteins during promotion of gamma-glutamyl transpeptidase-positive hepatic foci and inhibition by DEHP. Cancer Res 45 2654-2660. 

Rao MS, Usuda N, Subbarao V, et al. 1987. Absence of gamma-glutamyl transpeptidase activity in neoplastic lesions induced in the liver of male F -344 rats by di-(2-ethylhexyl)phthalate, a peroxisome proliferator. Carcinogenesis 8 1347-1350. 

Gossett KA, Turnwald GH, Kearney MT et al. (1987) Evaluation of gamma-glutamyl transpeptidase-to-creatinine ratio from spot samples of urine supernatant, as an indicator of urinary enzyme excretion in dogs. Am J Vet Res 48 455-457... 

Stable pool of GSH as degradation is initiated by extracellular gamma-glutamyl transpeptidase... 

Gamma-glutamyl transpeptidase (GGT, y-GT) Biliary epithelia, hepatocytes 0-50 lU/L Raised in many forms of liver disease and in enzyme induction, e.g. alcohol or certain medicines... 

---