Filtered bicarbonate

Preparation of Intermediate Compound 2-Methyl-3-o-Tolyl-6-Sulfamyl-7-Chloro-4(3H)-Quinazoiinone Set up a 5-liter 3-necked flask fitted with a stirrer, condenser and a drying tube. To a stirred mixture of 100 g (0.342 mol) of powdered 4-chloro-5-sulfamyl-N-acetylanthranilic acid, 40.2 g (0.376 mol) of o-toluidine and 2.0 liters of dry toluene was added dropwise, over a period of 15 minutes, 21.7 ml (34.1 g) (0.248 mol) of phosphorus trichloride. The mixture was then refluxed for 10 hours. The solid turned somewhat gummy towards the latter part of the first hour. The mixture then became more free flowing as heating was continued. Let stand overnight. The yellow solid was filtered, washed with toluene and dried. The toluene filtrate was discarded. The dried solid was triturated with 1.5 liters of 10% sodium bicarbonate, filtered and the cake washed with water. The filtrate on acidification yielded 11.5 g of the starting acid. The damp product was dissolved in 4,5 liters of 95% ethanol and the solution treated with charcoal and filtered. On cooling filtrate yielded 69.5 g (55.5%) of the title compound, MP 271.5° to 274°C. 

The 3-acetamido-5-methoxycarbonyl-2,4,6-triiodobenzoyl chloride was dissolved in a mixture of dioxan and dimethylformamide. In the course of 2 h this solution was added dropwise to a solution of ethanolamine and triethylamine in dioxan. The stirring was continued. A sticky precipitate was filtered off. The filtrate was evaporated to dryness in vacuo. The residue was triturated with aqueous sodium bicarbonate, filtered off and mixed with first fraction. The combined solids were then suspended in aqueous sodium bicarbonate filtered off washed with water and dried in vacuo to give methyl 5-acetamido-2,4,6-triiodo-(N-p-hydroxyethyl)-isophthalamate. 

C) Preparation of 7-Chloro-2,3-Dihydro-l-Methyl-5-Phenyl-lH-l,4-Benzodiazepine A mixture of 4.7 g (22.6 mol) of 7-chloro-l,2,3,4-tetrahydro-l-methyl-5H-l,4-benzodiazepin-5-one and 100 ml of phosphorus oxychloride was heated in an oil bath at 100°C for 15 minutes. The solution was concentrated to dryness in vacuo. The residue was partitioned between methylene chloride and cold saturated sodium bicarbonate solution. The methylene chloride phase was dried over sodium sulfate and sodium bicarbonate, filtered, diluted with benzene and concentrated in vacuo to produce crude 5,7-dichloro-2,3-dihydro-l-methyl-lH- 1,4-benzodiazepine. 

The dried solid was triturated with 1.5 liters of 10% sodium bicarbonate, filtered and the cake washed with water. The filtrate on acidification yielded 11.5 g of the starting acid. The damp product was dissolved in 4.5 liters of 95% ethanol and the solution treated with charcoal and filtered. On cooling filtrate yielded 69.5 g (55.5%) of the title compound, MP 271.5° to 274°C. 

Slurry drawn from the crystallizing columns is filtered in rotary vacuum filters where the NaHC03 crystals are water-washed. The filtered liquor then flows to the distillation unit for recovery of ammonia. The crude bicarbonate filter cake contains 3 percent... 

Adjust 100 ml of urine to pH 4.0 with dilute sulphuric acid, extract with 100 ml of chloroform, wash the solvent layer with a 5% solution of sodium bicarbonate, filter the solvent through a phase-separating paper, and evaporate to yield the Acid Fraction. If either frusemide or salicylic acid is suspected, adjust the pH of the sodium bicarbonate layer to 4.0 with dilute sulphuric acid, extract with 25 ml of ether, and retain the ether extract for analysis. 

Sodium bicarbonate is also used in cleaning products on both a household and industrial level. Many householders use commercial baking soda, such as that sold by the Arm Hammer company, to clean kitchen and bathroom appliances, such as sinks, stoves, and toilet bowls. Industries also use sodium bicarbonate filters to remove sulfur dioxide and other pollutants in flu gases released from factory smokestacks. The compound is also used in the treatment of wastewater to maintain proper acidity, remove certain odors (such as those of sulfur dioxide), and destroy bacteria. Some communities have used aqueous solutions of sodium bicarbonate sprayed at high pressure to remove graffiti paint soot and smoke residues and mold from buildings, walls, and other public structures. 

The sugar (100 mg) is suspended in toluene (20/il), cyclohexanone ethylene acetal (700/il) and a drop of concentrated sulphuric acid, and the mixture is refluxed for 6h, then neutralized with solid sodium bicarbonate, filtered and evaporated to dryness under reduced pressure. Analysis is by TLC using toluene/ethanol (9 I) as solvent ]26]. 

Sample preparation Prepare a 1 mg/mL solution in 12.5 mM ammonium bicarbonate, filter (0.45 pm), inject an aliquot. 

Ammonia Method.—The acid (about i gram) is dissolved in excess of alcoholic potassium hydroxide, and made up to 250 cc with alcohol of the same strength (93 per cent). The excess of alkali is neutralized by carbonic anhydride, the precipitated carbonate and bicarbonate filtered off and washed with 50 cc of alcohol (98 per cent). The alcohol is removed from the filtrate and washings by distillation, and the... 

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