Corticotropin-releasing hormone-binding protein

In response to energy demands, the fatty acids of stored triacylglycerols must be mobilised for use by peripheral tissues. This release is controUed by a complex series of interrelated cascades that result in the activation of hormone-sensitive lipase. In adipocytes this stimulus can come from glucagon, adrenaline (epinephrine) or 8-corticotropin. These hormones bind cell-surface receptors that are coupled to the activation of adenyl cyclase the resultant increase in intracellular cAMP leads to activation of cAMP-dependent protein kinase, which in turn phosphorylates and activates hormone-sensitive lipase (Figure 5.5). 

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