Corticosteroids atopic eczema

Billich A, Aschauer H, Aszodi A, Stuetz A. (2004) Percutaneous absorption of drugs used in atopic eczema Pimecrolimus permeates less through skin than corticosteroids and tacrolimus. Int J Pharm 269 29-35. 

In AD increased S. aureus colonization plays a fundamental role therefore, antistaphylococcal therapy is part of a successful management of the disease. Epidermal lipid deficiencies and barrier dysfunction contribute to enhanced S. aureus attachment to the skin and mediate immunological and inflammatory effects including the release of superantigens, additional exotoxins, and exoenzymes, and perhaps bacterial DNA-triggered mechanisms. Therapeutic possibilities include the use of topical antiseptics in cases of microbial-laden atopic eczema, corticosteroids, and specific antibiotic-antiseptic combinations in cases of localized superinfected atopic eczema and systemic antibiotics in cases of generalized superinfected atopic eczema.48... 

Brockow, K. et al., Effect of gentian violet, corticosteroid and tar preparations in Staphylococcus-aureus-colonized atopic eczema. Dermatology 199, 231-236, 1999. 

Charman CR, Morris AD, Williams HC. Topical corticosteroid phobia in patients with atopic eczema. Br J Dermatol 2000 142 931-936. 

Johnson (73 -) conducted an interesting experiment in which he proved that in a number of skin conditions simple protective applications are quite effective, and that the use of topical corticosteroids is superfluous. Especially those conditions which are characterized by dryness, scaling and cracking of the skin, and in which environmental aspects are likely to be involved, responded well. These were xeroderma, winter (asteatotic) eczema and atopic eczema with dryness and cracking. Simple preparations are especially recommended by this author in skin conditions the cause of which is clearly traumatic in the sense that everyday activities associated with work, the home and leisure, unavoidably have a traumatic component. 

Pruritus Relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses Contact dermatitis, atopic dermatitis, nummular eczema, stasis eczema, asteatotic eczema, lichen planus, lichen simplex chronicus, insect and arthropod bite reactions, first- and second-degree localized burns, and sunburns. 

---