Cortical bone effects

GAO Y H and YAMAGUCHI M (1999c) Anabolic effect of daidzein on cortical bone in tissue culture Comparison with genistein effect. Mol Cell Biochem 194, 93-8. 

Among the oldest women with impaired calcium balance a high caffeine intake may predispose to cortical bone loss. However, effects were age and site specific and after... 

Chavassieux P, Garnero P, Duboeuf F, Vergnaud P, Brunner-Ferber F, Del-mas PD, et al (2001) Effects of a new selective estrogen receptor modulator (MDL 103,323) on cancellous and cortical bone in ovariectomized ewes a biochemical, histomorphometric, and densitometric study. J Bone Miner Res 16 89-96... 

Prior to the work of Kazanski et al. there was almost no mention of polarization effects in the bone Raman literature, although the polarized Raman spectrum of dental enamel was reported as early as 1994 [36]. The reason may well be that most Raman spectra of cortical bone have been obtained by... 

By monitoring the H MAS spectra, it has been suggested that the loss of water from bone tissue is an irreversible process under air drying conditions.38 It has been shown that CP transfer within an isolated heteronuclear spin pair will exhibit a characteristic oscillation, from which the dipolar coupling constant can be accurately determined.197 The technique of LG-CPMAS can probe this oscillation pattern due to a dominating 31P-1H interaction in a dipolar coupled network, if any. However, such oscillation is seldom observed in 31P 1H CPMAS measurements of biominerals because of the damping effect of the homonu-clear dipole-dipole interaction. Thus, it is rather remarkable that the buildup curve of 31P 1H LG-CPMAS obtained for a sample of powdered femoral cortical bone, which is partially hydrated, shows a distinctive... 

An in situ detection of the dehydration effect on bovine cortical bone samples has been carried out using 13C 1H CPMAS and 1H MAS.199 Figure 15 shows the dehydration process manifested in the NMR spectra. The dehydration-induced line broadening shown in the 13C spectra has been attributed to a local conformational disorder of the bone matrix and... 

Carboxyethylgermsesquioxane can inhibit bone resorption by osteoclasts in a concentration-dependent manner . The therapeutic effect of 2-carboxyethylgermanium sesquioxane (Ge-132) for experimental osteoporosis has been studied using ovariectomized rats maintained on a low calcium containing diet. The Ge-132 decreased the bone strength, and affected the femur cortical bone index and bone mineral mass caused by osteoporosis . ... 

Estrogen inhibits osteoclast-mediated resorption of cancellous and cortical bone by a direct effect on the osteoclasts and... 

Bone composition, such as mineralizahon, carbonate accumulation, crystallinity and collagen crosslinking, has been shown to change with age [41], and is correlated with the bone s mechanical properhes [42, 43]. In microdamaged bone, the collagen crosslinking is altered but the mineralization and crystallinity are unaffected [44] (Figure 14.6). Alterahons in bone composition have been observed in diseases such as osteoporosis [45], osteopetrosis [46] and osteoarthritis [47]. The treatment of osteoporosis with nandrolone decanoate, an anabolic steroid, was shown to alter the cortical bone composition [48], whereas treatment with bisphos-phonates had little effect [49]. 

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