Correlations major depression

Plants affecting the serotoninergic neurotransmission are therefore interesting because of their potentials for the treatment of depression, which is the eighth leading cause of death in the United States. It is generally agreed that there is a correlation between diminished serotonin neurotransmission and episodes of major depression, and a number or inhibitors of serotonin-uptake inhibitors are available on the market, such as sertraline (Zoloft ). 

Milak, M. S., Parsey, R. V., Keilp, J. et al. Neuroanatomical correlates of psychopathological components of major depressive disorder. Arch. Gen. Psych. 62 397-408, 2005. 

The antithromboxane effect of ginger is of potential significance in stress and depression. Hypercortisolism is found in approximately 50% of patients with major depression. Plasma thromboxane B levels correlated in a group of depressed patients with high levels of cortisol, but not with depressed individuals with low cortisol or with normal controls... 

Similarities between the Effects of Stress and Neurobiological Correlates of Major Depressive Disorder in Adults... 

Studies at the National Institutes of Health (NIH) have detailed the clinical characteristics of patients in the PANDAS subgroup (Swedo et al., 1998). The rate of neuropsychiatric comorbidity in this population is quite striking. Twenty of the 50 children (40%) met DSM-IV criteria for ADHD and/or oppositional defiant disorder (ODD), 18 (36%) for major depressive disorder, 14 (28%) for overanxious disorder, and 10 (20%) for separation anxiety disorder. Six children (12%) were enuretic, often episodically and closely correlated with periods of OCD and tic exacerbations. Depressive symptoms, ADHD, and separation anxiety disorder also waxed and waned in concert with the OCD/ tic symptoms. In addition, exacerbations of OCD and tics were accompanied frequently by the acute onset of choreiform movements (clinically distinct from chorea), emotional lability and irritability, tactile/sensory defensiveness, motoric hyperactivity, messy handwriting, and symptoms of separation anxiety (Perlmutter et al., 1998 Becker et al., 2000). 

I. F. Small et al. 1986), and in our experience the same may hold true for some young patients with schizophrenia. However, confounding variables such as age and gender have not been addressed in these studies. In patients with major depressive disorder, we found no relation between seizure threshold and unipolar versus bipolar or psychotic versus nonpsychotic subtypes. Similarly, Coffey et al. (1995a) found no correlation between initial seizure threshold and severity of depressive illness or the unipolar-bipolar distinction. Finally, we found that history of ECT did not predict seizure threshold (Krueger et al. 1993). 

Jeste DV, Eastham JH, Lohr JB, et al Treatment of disordered behavior and psychosis, in Clinical Geriatric Psychopharmacology, 3rd Edition. Edited by Salzman C. Baltimore, MD, Williams Wilkins, 1998, pp 107-149 Jimerson DC, Post RM, Carman JS, et al CSF calcium clinical correlates in affective illness and schizophrenia. Biol Psychiatry 14 37-51, 1979 Joffe RT, Levitt AJ Major depression and subchnical (Grade 2 hypothyroidism. 

Druss, B.G., Hoff, R.A., Rosenheck, R.A. Underuse of antidepressants in major depression prevalence and correlates in a national sample of young adults. J. Clin. Psychiatry 61, 234-237, 2000. 

In Taiwan, Huang et al. investigated the correlation between serum lipid, lipoprotein concentrations and major depressive disorder in patients admitted for general health screening [33]. They found that the ratios of TC/HDL and LDL/HDL showed significant differences between patients with major depressive disorder and normal controls in women. Huang and Chen also pointed out that no significant differences were found in lipid concentrations of TC, TG, HDL, VLDL, LDL, TC/HDL, and LDL/HDL between patients with dysthymia and normal controls [41],... 

Although there are papers that discuss the relationships between cholesterol, lipid profiles, and major depression [34-39], there are few data that discuss the association between lipid profiles and depressive disorders with different phenotypes. Huang and Chen investigated the correlation between serum lipid, lipoprotein concentration, and major depressive disorder in patients evaluated for general health screening [41]. They found that analysis of covariance after age adjustment revealed significant differences in patients with melancholic feature and patients with atypical feature in serum concentrations of TG and VLDL in men and HDL in women [41]. However, there are still no reports that discuss the relationships between lipid profiles and major depression with postpartum onset or catatonic feature. In the future, large sample numbers will be needed to clarify the clinical differences in this field. 

Huang TL, Wu SC, Chiang YS, Chen JF. Correlation between serum lipid, lipoprotein concentrations and anxious state, depressive state or major depressive disorder. Psychiatry Res 2003 118 147-153. 

Zubenko GS, Moossy J (1988) Major depression in primary dementia. Clinical and neuropathologic correlates. Arch. Neurol. 45 1182-1186. 

The proinflammatory cytokine found to have increased levels in plasma and CNS in major depressive illness and whose levels correlate significantly with mood rating is... 

A well-established biological correlate for major depressive disorder involves... 

Few studies have prospectively documented the degree of functional impairment before or after specific treatments or have evaluated the pharmacoeconomic differences in treatments for premenstrual and perimenopausal disorders. Data on the economic burden (i.e., health care utilization, related costs, and the loss of productivity) from different menstrual-related disorders are still lacking. Several PMDD studies have reported greater improvement in psychosocial functioning and work capacity with SRls compared with placebo. In all studies, the degree of functional impairment was substantial at baseline and similar to that seen in studies of major depression. The functional improvement correlated with the improvement in premenstrual symptoms and was evident by the second cycle of treatment. 

Major depression is a complex disorder with a highly variable course and an inconsistent response to treatment—and no established biogenic or psychogenic mechanism.55 We really don t understand it, we don t know how to treat it in all cases, and we don t know what causes it. We have only some intriguing correlations. 

Vitamin B12J B12 and folic acid work together in a powerful combination Both help the brain produce needed neurotransmitters and help to reduce inflammation. B12 can be a powerful antidote to depression A study published in the Journal of Psychosomatic Research found that men who had lost a partner in the last six months suffered more intensely from depression, anxiety, and confusion if their B12 levels were low. A study among seven hundred women above the age of sixty-five found a clear correlation between depression and B12 deficiency. The more severe the depression, the higher the correlation. And a Finnish study comparing the responses of people with major depression to antidepressants found that people with higher B levels did relatively better than those with lower levels. ... 

Gardner, A., Johansson, A., Wibom, R., Nennesmo, 1., von Dobeln, U., Hagenfeldt, L., and HaUstrom, T. 2003. Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients. 1. Affect. Disord. 76 55-68. 

---