Cordyceps militaris

Cordyceps militaris (fungus) Metabolite Cordycepin-5 -triphosphate yields 3 -Deoxyadenosine-5-monophosphate (3 -dAMP)... 

Cordycepin (Cordyceps militaris and Aspergillus nidulans) B-70MI40900, p. 50... 

Amino-3 -deoxyadenosine (plus 3 -N-acetylhomocitrullyl and lysyl) (Helminthosporium, Cordyceps militaris and Aspergillus nidulans) B-70MI40900, p. 176... 

The mold Cordyceps militaris Linn, contains an antibiotic substance, cordycepin (15) which, on acid hydrolysis, gives adenine and a deoxyaldo-pentose that was named cordycepose. The ultraviolet spectrum of the nucleoside indicates that the sugar is attached to the 9-position of adenine, but the complete structure of the su moiety of cordycepin has not been elucidated. 

The connection of anamorphic insect pathogens to Cordyceps was first made by Tulasne (1857), who wrongly inferred Paecilomycesfarinosus to be the anamorph of Cordyceps militaris. Although corrected by the careful work of de Bary and Petch, this misconception persisted in the literature through the late 1900s. 

Few teleomorph connections have been demonstrated for Paecilomyces. Paecilomyces farinosus was once erroneously considered the anamorph of Cordyceps militaris (Tulasne, 1857). More recently, P. farinosus has been suggested to be the anamorph of Cordyceps memorabilis (Pacioni and Frizzi, 1978). Hywel-Jones (1993) demonstrated that Torrubiella luteorostrata is the teleomorph of P. cinnamomeus. The latter species also produces an Acremonium-like synanamorph in culture (Hywel-Jones, 1993), and this has since been found in field-collected material (N. L. Hywel-Jones, personal communication). 

The recently described genus Hyperdermium (Sullivan et al., 2000) exhibits a novel anamorph that the authors compared to the Hypocrealean anamorph, Cylindrocarpon. It produces simple aculeate phialides and the conidia are multiseptate and accumulate in a microsclerotium-like mass which apparently functions as a diaspore. Sullivan et al. (2000) inferred a relationship between Hyperdermium and Cordyceps militaris based on molecular data. Further taxon sampling is needed to elucidate the nearest relatives of Hyperdermium. 

Basith M, Madelin MF. Studies on the production of perithecial stromata by Cordyceps militaris in artificial culture. Can J Bot 46 473-480, 1968. 

Sato H, Shimazu M, Kamata N. Detection of Cordyceps militaris Link (Clavicipitales Clavicipitaceae) by burying pupae of Quadricalcarifera punctatella Morschlsky (Lepidoptera Notodontidae). Appl Entomol Zool 29 130-132, 1994. 

Cordycepin O -deoxyadenosine 152), isolated from Cordyceps militaris (Cunningham et al., 1951 Bentley et al., 1951), is a deoxynucleoside possessing antifungal, antiviral, and antitumor activity. Although (152) was isolated 50 years ago, there are still an increasing number of publications on the biochemistry of this compound and other nucleoside mimics. It should be noted that an adenosine derivative, N 6-(2-hydroxyethyl) adenosine (153), was isolated, together with (152) and adenosine, from several species of Cordycepsand Isaria (Furuya et al., 1983). 

Cordyceps militaris Cordycepin (152) Deoxynucleoside Antivirus, antitumor 1951... 

Bentley HR, Cunningham KG, Spring FS. Cordycepin, a metabolic product from cultures of Cordyceps militaris (Linn.) Link. Part II. The structure of cordycepin. J Chem Soc 2301-2305, 1951. 

Zhao-Long W, Xiao-Xia W, Wei-Ying C. Inhibitory effect of Cordyceps sinensis and Cordyceps militaris on human glomerular mesangial cell proliferation induced by native LDL. Cell Biochem Funct 18(2) 93-97, 2000. 

Cordycepin, a metabolic product of the fungus Cordyceps militaris (Linn) Link, shows antibacterial activity against Bacterium mbtilis... 

Cordyceps militaris (Fries) Link—147 Cordyceps ophioglossoides (Fries) link—147,... 

Cordyceptin (313) is a fermentation product of the fungi Aspergillus nidulans and Cordyceps militaris. Cordyceptin inhibits the synthesis of mRNA and hence the replication of both RNA and DNA viruses [18]. 

Kim SW, Hwang HJ, Xu CP et al. (2003) Optimization of submerged culture process for the production of mycelial biomass and exo-polysaccharides by Cordyceps militaris C738. J Appl Microbiol 94(1) 120-126... 

CioHijNjO, Mr 251.24, needles, mp. 225 -226°C, [oId -47° (H2O), well soluble in water. Metabolite from culture broths of Cordyceps, Isaria, Emericella, and Aspergillus species. C. exhibits strong cytotoxic activity by inhibition of RNA biosynthesis. Because of this property C. is used for investigations on messen-ger-RNA transcription. C. was the first nucleoside antibiotic to be described (1951) and was isolated from Cordyceps militaris. C. selectively inhibits the poly-adenylation of hnRNA in HeLa cells at 50 pg/mL. Furthermore not only 45S-rRNA biosynthesis but also adenylate cyclase are inhibited. 

The nucleoside cordycepin was isolated from cultures of the fungus Cordyceps militaris and found to be 3 -deoxyadenosine. Write its structural formula. 

Zhang, Z., Lu, G., Pan, H., Fan, L., Soccol, C. R., Pandey, A. (2012). Production of powerful antioxidant supplements via solid-state fermentation of wheat Triticum aestivum Linn.) by Cordyceps militaris. Food Technology and Biotechrwlogy, 50, 32-39. 

Amino-3 -deoxyadenosine a purine antibiotic synthesized by Cordyceps militaris and Helmintho-sporium species (see Nudeoside antibiotics). It has antitumor activity. The acetylated derivative, 3 -acet-amido-3 -deoxyadenosine, has also been isolated ftom Helminthosporium species... 

Amino- 3 -deoxyadenosine Cordyceps militaris, Helminthosporium spp. Adenine 3-Amino- 3-deoxyribose Adenosine... 

Cordycepin Cordyceps militaris, Aspergillus nidulans Adenine Cordycepose (3-Deoxytibose) Adenosine... 

Figure 1-3 shows a number of nucleoside antibiotics which contain adenine and an unusual sugar at the 9-position. Cordycepin (3 -deoxy-adenosine) is a cytostatic agent and is converted to the 5 -mono-, di-, and triphosphate derivatives in mouse tumor cells. Cordyceps militaris, the organism which produces cordycepin, also produces a related analogue with antitumor activity, 3 -amino-3 -deoxyadenosine this compound is also metabolized by way of phosphate derivatives. The angustmycins, psicofuranine and decoyinine, are, respectively, the 9-j3-D-psicofuranosyl... 

CioHmNsOj 266.259 Nucleoside antibiotic. Obt. from the mould Cordyceps militaris and from Helminthosporium spp. culture filtrates. Antineoplastic agent. Sol. MeOH, DMF fairly sol. EtOH poorly sol. H2O, butanol, hexane, THE... 

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