Convulsions treatment

Ehrhardt, H. 1966, Present status of insulin coma and electric convulsive treatment in Germany, in Biological Treatment of Mental Illness, M. Rinkel, ed., Farrar, Straus Giroux, New York. 

Janis, I. L. (1950). Psychological effects of electric convulsive treatments. Journal of Nervous and Mental Disease, 111, 359—397, 469—489. 

Sensitivity to Convulsant Treatments - PCPA facilitates convulsions el-Icited by hyperbaric oxygen,39 pentylenetetrazolelectroconvulsive shock, Oa,41 audiogenic convulsant stimuli,42 flurothyl43 and withdrawal from barbiturates.44 a substantial older literature, originating with the work of Chen et al45 on reserpine, deals with the role of biogenic amines in experimental seizures. The preponderance of these reports indicate that stimulation of 5-HT receptor activity decreases seizure susceptibility, and that depression of 5-HT receptor activity exerts the opposite effect. 

Many patents have been issued on the use of pyrogaUol derivatives as pharmaceuticals. PyrogaUol has been used extemaUy in the form of an ointment or a solution in the treatment of skin diseases, eg, psoriasis, ringworm, and lupus erythematosus. GaUamine triethiodide (16) is an important muscle relaxant in surgery it also is used in convulsive-shock therapy. Trimethoprim (2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine) is an antimicrobial and is a component of Bactrin and Septra. Trimetazidine (l(2,3,4-trimethoxybenzyl)piperazine (Vastarel, Yosimilon) is used as a coronary vasodilator. l,2,3,4-Tetrahydro-6-methoxy-l-(3,4,5-trimethoxyphenyl)-9JT-pyrido[3,4- ]indole hydrochloride is useful as a tranquilizer (52) (see Hypnotics, sedatives, ANTICONVULSANTS, AND ANXIOLYTICS). Substituted indanones made from pyrogaUol trimethyl ether depress the central nervous system (CNS) (53). Tyrosine-and glycine(2,3,4-trihydroxybenzyl)hydrazides are characterized by antidepressant and anti-Parkinson activity (54). 

Toxopyrimidine (pyramin lOlO) may be obtained from thiamine (vitamin Bi 1011) by acidic hydrolysis or by treatment with the thiaminase of Bacillus aneurinolyticus. Toxopyrimidine produces convulsions and death in rodents as do analogues, e.g. 2,4-dimethylpyrimidin-5-ylmethanol (1012) (65JMC750), but the effect is minimized or even... 

Health Hazards Information - Recommended Persoruil Protective Equipment Fresh air mask for confined areas rubber gloves protective clothing full face shield Symptoms Following Exposure Will bum eyes and skin. The analgesic action may cause loss of pain sensation. Readily absorbed through skin, causing increased heart rate, convulsions, and death General Treatment for Exposure ... 

Health Hazards Information - Recommended Personal Protective Equipment Eye protection Symptoms Following Exposure Vapors from very hot material may irritate eyes and produce headache, drowsiness, and convulsions General Treatment for Exposure Remove fresh air. Wash affected skin areas with water. Flush eyes with water Toxicity by Inhalation (ThresholdLimit Value) 5 mg/m Short-Term Exposure limits Not pertinent Toxicity by Ingestion Grade 1 LDjq 5 to 15 g/kg Late Toxicity Birth defects in rats polyneuritis in humans Vapor (Gas) Irritant Characteristics Not pertinent liquid or Solid Irritant Characteristics No appreciable hazard. Practically harmless to the skin Odor Threshold Data not available. 

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