Convective interaction media

Most of the SMC presented in this chapter are highly cross-finked porous rigid monolithic polyglycidylmethacrylate-co-ethyleneglycoldimethacrylate or styrene-divinilybenzene polymers produced by BIA Separations under the trade name of Convective Interaction Media (CIM). Following the idea of a short chromatographic layer, the smaller units are produced in the form of disks (see Fig. 6) and the larger units in the form of tubes (see Fig. 4). [Pg.71]

Several research groups, for instance, reported on the generation of weak anion exchanges by reacting the epoxy functionalities with diethylamine [54-57], The resulting diethylaminoethyl monoliths—which are commercially available as CIM (Convective Interaction Media) in disk and column format—have frequently been used for protein and oligonucleotide separation [58] as well as for the purihcation of proteins and plasmid DNA [59-61]. [Pg.11]

There are other novel media with characteristics similar to functionalized membranes. Some of the commercially available media are listed in Table 2. These materials in many cases are at the cross-lines of definitions and are frequently compared in the MA literature. Organic separations in the reserve-phase (RP) and hydrophobic interaction chromatography (HIC) mode are not very common on filtration-based MA materials. However, the methacrylate copolymers can be used for this purpose. Also rodlike monolithic materials enable greater flexibility in these types of chemistry.13,14 The method of Tennikova and Svec15-17 has been used to commercialize a novel disk type separation media, called CIM (Convective interaction media, BIA, Ljubljana, Slovenia).18-21 Analytical-scale separations can be performed on... [Pg.456]

CIM disk (convective interaction media) BIA, Ljubljana, Slovenia Disk/monolith formed by copolymer 19-21... [Pg.457]

Strancar, A. Bamt, M. Podgornik, A. Koselj, P. Josic, Dj. Buchacher, A. Convective interaction media Polymer-based supports for fast separation of biomolecules. LC GC 1998, 11, 660 669. [Pg.1026]

Podgornik, H. Podgornik, A. Perdih, A. A method of fast separation of lignin peroxidases using convective interaction media disks. Anal. Biochem. 1999, 272, 43-47. [Pg.1026]

Vodopivec, M. Podgornik, A. Berovic, M. Strancar, A. Application of Convective Interaction Media (CIM ) disk monolithic columns for fast separation and monitoring of organic acids. JCS 2000, 38 (11), 489-495. [Pg.1026]

Svete, P. Milacic, R. Mitrovic, B. Pihlar, B. Potential for the speciation of Zn using fast protein liquid chromatography (FPLC) and convective interaction media (CIM ) fast monolithic chromatography with FAAS and electrospray (ES)-MS-MS detection. Analyst 2001, 126, 1346-1354. [Pg.1026]

Convective interaction media (CIM) are supports which are related to Frechefs monoliths. They are block polymers prepared by radical copolymerization of glycidyl methacrylate and ethylene dimethacrylate in the presence of... [Pg.218]

Based on the results above and experiences reported in literature on convective interaction media (CIM) discs, it is obvious that macroporous chromatographic materials have good potential for isolation of virus particles [64]. [Pg.263]

Source From Convective interaction media polymer-based supports for fast separation of biomolecules, in LC... [Pg.1529]

Monoliths are also extensively used on an analytical scale. SUica-based monoliths, commercialized under the trade name Chromolith (Merck, Darmstadt, Germany), exhibit high resolving power, combined with a very low pressure drop and seem to be an ideal support for many small molecule applications. On the other hand, methacrylate based monoliths, commercialized by BIA Separations (Ljubljana, Slovenia) under the trademark CIM Convective Interaction Media , are widely used for separation and purification of large molecules such as proteins, DNA, or even viruses. ... [Pg.1532]

Mihelic, I. Koloini, T. Podgomik, A. Strancar, A. Dynamic capacity studies of CIM (Convective Interaction Media) monolithic columns. J. High Resolut. Chromatogr. [Pg.1538]

A. Podgornik and A. Strancar, Convective Interaction Media (CIM)-short layer monolithic chromatographic stationary phases, Biotechnol Annu. Rev., 2005,11, 281-333. [Pg.355]

FTIR Citric and malic acid, glucose, fructose, sucrose Orange, grape, and apple juice, lemon drink, other soft drinks Sequential injection, convective interaction media (CIM) disk separation, multivariate calibration for spectral data resolution, inline calibration standard preparation from a single standard solution 0.2-9.0 g/L Lethanh and Lendl (2000)... [Pg.290]

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