Glycosphingolipids binding

Delorme C, Bmssow H, Sidoti J, Roche N, Karlsson KA, Neeser JR, Teneberg S (2001) Glycosphingolipid binding specificities of rotavirus identification of a sialic acid-binding epitope. J Virol 75 2276-2287... 

Fantini J, Yahi N. Molecular basis for the glycosphingolipid-binding specificity of alpha-synuclein key role of tyrosine 39 in membrane insertion. / Mol Biol. 2011 408(4) 654-669. 

Chakrabandhu K, Huault S, Garmy N, et al. The extracellular glycosphingolipid-binding motif of Fas defines its internalization route, mode and outcome of signals upon activation by ligand. Cell Death Differ. 2008 15(12) 1824 1837. 

Heuss SF, Tarantino N, Fantini J, et al. A glycosphingolipid binding domain controls trafficking and activity of the mammalian notch ligand delta-Kke 1. PloS One. 2013 8(9) e74392. 

Integrins associate with the membrane protein caveolin.34 Although little is yet known about this particular interaction, it could assist in forming integrin clusters at the plasma membrane which might serve as a scaffold for the assembly of multi-component signalling complexes. This possibility is attractive, because caveolin binds cholesterol and glycosphingolipids and forms membrane rafts , enriched in myristoylated and palmitoy-lated Src-family kinases (Chapter 8).35... 

A non-natural glycosphingolipid inhibited caveolar uptake, viral binding and infectivity, and 31-integrin signaling... 

---