Controlled drug delivery technology

Controlled drug delivery technology represents one of the most rapidly advancing areas of science. Such delivery systems offer numerous advantages over conventional dosage forms, including improved efficacy, reduced toxicity, improved patient compliance, and convenience. Therefore, all controlled release systems aim to improve the effectiveness of drug therapy and can be achieved via temporal and/or distribution control of dmg release. 

Porous polymer materials, especially in particulate form, are of interest in a diverse range of applications, including controlled drug delivery, enzyme immobilization, molecular separation technology, and as hosts for chemical synthesis [101-104]. MS materials have been used as hosts for the template synthesis of nanoporous polymer replicas through in situ polymerization of monomers in the mesopores [105-108]. 

Controlled drug delivery, membrane technology in, 15 847-848 Controlled drug release formulations (CDRFs), 9 51, 55 polymers in, 9 71-73 Controlled drug release systems, 9 50-51 design, 9 51-52 development, 9 55-57 intelligent, 9 56-57 in market, 9 83—85... 

Membrane separators, 23 795-796 Membrane/sonication/wet oxidation (MEMSONIWO) systems in wastewater treatment, 25 911-912 Membrane systems, as advanced wastewater treatment, 25 909 Membrane technology, 25 796-852 applications for, 25 824-848 in controlled drug delivery,... 

L-ORO drug delivery technology, a proprietary controlled-release delivery system invented by ALZA Corporation (Mountain View, California), combines drug solubilization technology enabling... 

Wong, P, et al., Osmotically controlled tablets.Nfadified-Release Drug Delivery Technology, M.J. Rathbone, etal. (Eds.), Marcel Dekker, Inc. New York, 2003, p. 107. 

Lee, K., and Mooney, D. Controlled growth factor delivery for tissue engineering, in Dinh, S. and Liu, P (eds.), Advances in Controlled Drug Delivery Science, Technology, and Products. ACS Symposium Series 846, Washington, 2003, pp. 73-83. 

H. G. Zerbe and M. Krumme. Smartrix system Design characteristics and release properties of a novel erosion-controlled oral delivery system, in Michael J. Rathbone, Jonathan Hadgraft, and Machael S. Roberts (eds.), Drugs and the Pharmaceutical Sciences, vol. 126 Modified-Release Drug Delivery Technology. New York Marcel Dekker, 2003, pp. 59-76. 

Six developed and a number of developing and yet-to-be-developed industrial membrane technologies are discussed in this book. In addition, sections are included describing the use of membranes in medical applications such as the artificial kidney, blood oxygenation, and controlled drug delivery devices. The status of all of these processes is summarized in Table 1.1. 

FIGURE 3 (a) Vertical droplet flow created by controlled particle dispersion used in ViaNase ID (Kurve Technology, Bothell, WA). (b) Deposition pattern produced by controlled particle dispersion. (Reproduced from ref. 42 with permission from Drug Delivery Technology.)... 

Rothen-Weinhold, A., Dahn, M., and Gurny, R. (2000), Formulation and technology aspects of controlled drug delivery in animals, Pharm. Sci. Technol. Today, 3, 222-231. 

Wu, X. S. (1996), Controlled Drug Delivery Systems, Technology Publishing, Lancaster, PA. 

Narasimhan B. Accurate models in controlled drug delivery systems. In Wise DL, ed. Handbook of Pharmaceutical Controlled Release Technology. New York, Basel Marcel Dekker, 2000, pp. 155-209. 

Sam, A. Minutes of 5th International Pharmaceutical Technology Symposium on New Approaches to Controlled Drug Delivery Editions de Sante Paris, 1991 271-284. 

A transdermal therapeutic system is a rate-controlled drug delivery system which, applied to the surface of the skin, continuously releases the drug at a rate that will provide a desired steady-state plasma concentration for a specified duration. A candidate drug must possess high activity (i.e. be effective at low plasma concentrations) and efficiently penetrate the stratum comeum-, percutaneous absorption must be reliably consistent. Based on technological design there are four types of rate-controlled transdermal drug delivery system (Chien, 1987) ... 

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