Contents 2 Depletion Interaction

Figure 3.6 Effect of Ca2+ content on predicted values of osmotic pressure (H, , left axis) of caseinate nanoparticles in emulsion continuous phase and the free energy of the depletion interaction (AGdep, , right axis) between a pair of emulsion droplets (

Mitochondria-associated toxicities, such as pancreatitis, are frequently demonstrated in HlV/HCV-coinfected individuals, and may significantly influence treatment options (de Mendoza and Soriano 2005). Yet, no cell culture or animal models have been developed to predict nucleoside-induced pancreatitis. Nevertheless, an association of HCV replication and mitochondrial DNA depletion in primary human lymphocytes obtained from HIV/HCV-coinfected individuals under concomitant administration of HCV and HIV medications was demonstrated by de Mendoza and coworkers (de Mendoza et al. 2007). They claimed that the use of HCV medication together with certain antiretroviral agents seemed to enhance mitochondrial damage due to a synergistic deleterious interaction between the anti-HCV and anti-HIV drugs. In contrast, an improvement in mitochondrial content with effective... 

Fig. 9-4). Very low-density lipoprotein particles are released into the circulation where they acquire apolipoprotein E and apolipoprotein C-II from HDL. Very-low density lipoprotein loses its triglyceride content through the interaction with LPL to form VLDL remnant and IDL. Intermediate-density lipoprotein can be cleared from the circulation by hepatic LDL receptors or further converted to LDL (by further depletion of triglycerides) through the action of hepatic lipases (HL). Approximately 50% of IDL is converted to LDL. Low-density lipoprotein particles are cleared from the circulation primarily by hepatic LDL receptors by interaction with apolipoprotein B-100. They can also be taken up by extra-hepatic tissues or enter the arterial wall, contributing to atherogenesis.4,6... 

It is worthy of special interest to study directly the displacement of a herbicide by plastoquinone or its analogues. In normal thy-lakoids, almost no displacement of DCMU even by a million-fold excess of the short-chain plastoquinone analogue plastoquinone-1 can be observed (28). This may be due to the high endogenous plastoquinone content of the thylakoid membrane. If the thylakoids are depleted of plastoquinone by means of n-hexane extraction, a competitive displacement of DCMU by plastoquinone-1 is observed (28). This result establishes a direct interaction between herbicide and plastoquinone, though not necessarily at an identical binding site. From the displacement experiments, a binding constant for plastoquinone-1 of 51 19 jiM in plastoquinone-depleted thylakoids can be calculated (28). ... 

The interaction of cyclosporine with the plasma and tissue renin-angiotensin-aldosterone systems (RAS) has been extensively studied [21, 22]. Sodium depletion, a condition that stimulates renin release, enhances acute CSA nephrotoxicity [23, 24]. In rats, CSA treatment enhanced plasma renin activity (PRA) [21, 25, 26], increased renal renin content [21], promoted juxtaglomerular hypertrophy and hyperplasia [27,... 

Increasing levels of emulsification significantly depleted protein from the fat globule in the mix. The adsorbed protein content in the mix (mg m of fat surface area) correlated with major characteristic analyses describing the fat structure in ice cream (fat agglomerate size, fat agglomeration index, solvent extractable fat Fig. 6). Thus, the measurement of protein load in the mix can be used to predict ice-cream-fat stability and related structure. Structural analyses indicated enhanced interaction between fat and air as protein adsorption decreased. It was also observed that the fat content in the dripped portion collected from a meltdown test correlated well with other indices of fat destabilization. 

The uptake of iron by the human intestine is governed not only by its dietary form and companion consituents, but also by the iron condition of the individual. Iron-depleted subjects absorb all forms of iron with greater avidity than do iron-replete individuals. In human dietetics, therefore, the ascorbic content of a diet can be included in the equation for describing the bioavailability of iron from a mixed diet (35). The interaction of iron nutrition and graded intakes of ascorbic acid (< 25 mg > 25 but < 75 mg and > 75 mg) as a prediction of iron availability from a mixed North American diet is plotted in Figure 1. 

If melt or fluid re-enrichment or some other form of disturbance affects a peridotite subsequent to melting then this should be reflected in PGE patterns and PGE-major element syste-matics. Modelling of melt re-enrichment involving the addition of new sulphides to variably depleted melt residues during magma-solid interaction produces elevation of the Pd/Ir ratio to supra-chondritic levels, and elevated P-PGE contents (Rehkamper et al. 1999 Fig. 4). Combined major element, PGE and Re-Os isotope systematics therefore provide a potential means to evaluate the validity of Re-Os isotope model ages (Trd V. Tma)-... 

The Rho family GTPase Cdc42 directly interacts wilh/l/lC /l / to control filopodia formation, actin organization, and intracellular lipid transport (Diederich et al. 2001 Tsukamoto et al. 2001). We have previously shown (Drobnik et al. 2002) that ABCAl and Cdc42 were partially localized in Lubrol- but not in Triton-X DRMs and that apoA-I preferentially depleted unesterified cholesterol/phospholipids from Lubrol DRMs, whereas HDL3 additionally decreased the cholesterol content of Triton-X DRMs. 

It should be reminded here that the variation in cation distribution with A1 content is explained by considering short-range interactions only. The dominance of these forces is demonstrated by the h-KY samples with depleted K loading (with H/NH4 replacement for K) for a regular v composition, the sites I and II are the predominant sites, and this remains so for h-K H EAU and h-Ki 5. 2 (nr4) 39. 5FAIT (figure 1 and Table 3). 

Continued depletion of L-ascorbic acid in stored fruit-juices may be partly due to interaction with the hydrogen peroxide initially produced by aerobic mechanisms. Indeed, introduction of hydrogen peroxide, in amounts equivalent to the L-ascorbic acid content, into three-month old, blackcurrant-juice samples, caused a 50% loss of L-ascorbic acid in one hour, probably ascribable to formation of dehydro-L-ascorbic acid. 

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