Construction representative

Each relevant construct, representing an aspect of drug regulation structure, process or outcome, was analysed to show how and why a certain area of drug regulation does — or does not — work. 

The mode of association of peptides to liposome carriers might also be critical to induce a preferential immune response either humoral or cell mediated. For example, using a human mucin MUCl 20-mer peptide, it was found that only the physical association of the peptide to liposomes (either encapsulated or surface exposed after anchoring) was necessary to observe a cell-mediated response (34). In line with this observation, it was recently shown that a soluble peptide, representing a Melan-A/MART-1 tumor-associated antigen, when encapsulated into sterically stabilized liposomes, was able to stimulate a CTL response and this construct represented a suitable formulation for a specific tumor immunotherapy (69). In contrast, and in agreement with other studies (16), only the liposome surface exposed... 

Fig. 10.2 Effect of buffer composition on the ESI-FTICR-MS spectrum of a 27mer RNA construct representing the 16S A-site. The spectrum in (a) was acquired from a solution comprised of 33% isopropyl alcohol and 25 mM piperidine/imidazole with an approximate pH of 8.5. The spectrum in (b) was acquired from a solution containing the...

MAb-based constructs represent, as described, a heterogeneous class of anti-tumour agents with remarkable efficacy in the treatment of experimental cancers in animals. Several MAb and immunoconjugates have been evaluated further in cancer patients, and the results have indicated that some have activity at safe doses. 

Aziridines represent an important class of building block within synthesis. This structural motif is also embedded within a number of biologically significant natural products, and thus robust and efficient methods for their construction represent an important contribution to the synthetic toolkit. Cordova reported an enantiose-lective aziridination of a,P-unsaturated aldehydes catalysed by diarylprolinol ether 30 using protected hydroxylamine 91 as the nitrogen source (Scheme 38) [150]. The reaction was proposed to proceed via iminium ion formation followed by... 

Biological psychiatry, today, aims at elucidation of the biology of disease entities. This intention presumes the validity of those entities, but this premise is disputable. Many of the disease entities presently distinguished seem to represent, at best, basins of a variety of more or less comparable, but in many ways dissimilar, disorders. It is hard to believe that the search for particular brain dysfunctions underlying a diagnostic construct, representing in point of fact a diversity of disorders, stands much chance to score a success. 

At each stage of the project development the sequence and scope of the survey and the components consisting geotechnical conditions for the pipeline construction will be determined by taking into consideration the above-mentioned theoretical assumptions. While solving the issue the geotechnical conditions for the pipeline construction represent a determined common system of such interrelated system-generating components as ... 

An extension of this FTICR mass spectrometry-based screening technique has been to screen a combinatorial library for ligands to two receptors simultaneously (59, 60). In this example, the two receptors consisting of RNA constructs representing the prokaryotic (16s) rRNA and eukaryotic (18s) rRNA A-site were incubated simultaneously with an aminogly-... 

This industrial demonstration of the Spherizone process prompted commercialization of the technology, which was then made available for licensing to third parties. The development of units with capacities of up to 450 kta, presently under construction, represents a world-scale size for PP plants Spherizone maintains industry cost leadership with the capacity of the Spheripol technology. Up to the end of2007, nine Spherizone licenses, for a total capacity near 3 million ton per year, have been granted. 

A mathematical model may be constructed representing a chemical reaction. Solutions of the mathematical model must be compatible with the observed behavior of this chemical reaction. Furthermore if some other solutions would indicate possible behaviors so far unobserved, of the reaction, experiments maybe designed to experimentally observe them, thus to reinforce the validity of the mathematical model. Dynamical systems such as reactions are modelled by differential equations. The chemical equilibrium states are the stable singular solutions of the mathematical model consisting of a set of differential equations. Depending on the format of these equations solutions vary in a number of possible ways. In addition to these stable singular solutions periodic solutions also appear. Although there are various kinds of oscillatory behavior observed in reactions, these periodic solutions correspond to only some of these oscillations. 

Analysis of the Flexible flexible Pocketome core stem from the artificial crystallographic Experimental Pocketome constructs representing a particular protein, crystal packing, and... 

In 1837, the chemical explanation of fermentation was dealt a shattering blow by Charles Cagniard-Latour (1777-1859), Theodor Schwann (1810-1882) and Friedrich Kutzing (1807-1893) who had independent of each other rediscovered Leeuwenhoek s old observation of the yeast cell. This remarkable coincidence was due to improvements in microscope construction represented by the achromatic compound microscope, which had recently become available and gave much better... 

The tetrahedron construction represents the synthesis of sequential IPNs as well as the SINs. It must be noted that in real SIN syntheses, it is almost impossible to have the kinetics of polymerization of both polymers proceeding at identical rates. Sequential IPN polymerization represents the other extreme, where first one polymer is completely synthesized, and then the other follows sequentially. 

Formula construction represents a simplification of standard dateu It involves design of eilgebraic expression or a system of curves that establishes a time stemdeu d in advance of production by substitution of known values peculiar to the job for the variable elements. 

For climate protection construction material too needs to be selected according to ecological criteria. This is particularly important, because construction represents an essential economic element, also reflecting the intellectual and cultural value benchmark of a society. 

The above graphical constructs represent individual normal-ordered operators. Using these graphical representations one can derive all unique combinations (operator contractions) which contribute to the considered matrix element of an operator product. The rules for the diagram manipulations are standard and can be found elsewhere [13,51]. General-order coupled cluster equations can be derived from the general-order coupled cluster functional ... 

Our main aim is a complete system of representatives of the equivalence classes, a transversal, a complete collection of essentially different, i.e. pairwise inequivalent structures. The method of choice is the use of groups and of group actions which we describe next. The equivalence classes will turn out to be orbits of a suitable group, and this fact will allow us to count these classes, to construct representatives and even to generate representatives that are distributed uniformly at random over the equivalence classes, i.e. to generate samples. To begin we recall the notion of group ... 

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