Consolidation aggressive consolidators

In RPs, insufficient compaction and consolidation before plastic solidification or cure will result in air pockets, incomplete wet-out and encapsulation of the fibers, and/or insufficient fiber or uniform fiber content. These deficiencies lead to loss of strength and stiffness and susceptibility to deterioration by water and aggressive agents. 

In children, the intensity of the consolidation treatment is now determined not only by the child s risk classification but also by the rate of cytoreduction during induction.5 Patients who respond slowly to induction therapy (as determined by bone marrow examination early in induction) are at higher risk of relapse and are treated on more aggressive regimens. 

Consolidation has also created a pattern of aggressive and capital-intensive product acquisitions in recent years. These have, in turn, resulted in reduced credit ratings for many firms, stock share price declines, and most importantly, significant standing debts.This debt is further aggravated by plant closures and... 

Patients with disseminated MCL are usually treated with the same intensive combination chemotherapy regimens that are used in diffuse aggressive lymphomas. Overall response rates to these regimens is about 80%, with about one-half of patients achieving a complete response. Median progression-free and overall survival was 20 and 36 months, respectively. In patients who respond to initial therapy, interferon alfa may have a role as maintenance or consolidation therapy. Despite the high response rates, MCL is not considered curable with standard chemotherapy. Therefore younger patients who... 

Therapy for ALL has historically been divided into three phases (1) remission induction (2) consolidation therapy and (3) maintenance therapy (Fig. 131-1). Central nervous system (CNS) prophylaxis is a mandatory component of any ALL treatment regimen and is administered longitudinally during the induction and consolidation phases. Recently more complex regimens have been explored. All patients still receive induction therapy to yield a CR. Post-remission therapy is needed to treat microscopic disease and may include intensive inpatient therapy (consolidation or intensification therapy) followed by less aggressive outpatient therapy (maintenance or continuation). Tables 131-9 and 131-10 illustrate representative treatment regimens for adult and pediatric ALL. ° ... 

While maintenance therapy is considered inferior to intensive consolidation chemotherapy in younger patients, its role in older patients with AML is stiU undefined. Some studies suggest that maintenance therapy following consolidation prolongs DPS but not OS as compared to no maintenance therapy. Since older patients may not be able to tolerate more aggressive post-remission strategies such as HSCT, maintenance therapy may play an important role in improving outcomes. 

Site management organizations have aggressive aims to reengineer and overhaul the clinical development process through consolidating the fragmented and unsophisticated... 

Considering FA and TFS as consolidation additives, it should be noted that penetration of the SPC compositions modified by FA strongly depends on concentration of an aggressive environment. The polymerization rate of FA in the silicate media under the action of aggressive environments depends on pH, especially in the first reaction stages. Corrosion of silica by hydrofluoric acid occurs rather quickly and leads to loosening of the SPC composition and an increase of diffusive penetration. Consequently, application of the consolidation additive FA is desirable at pH < 5. 

Consolidation by alternative approaches. The latest approach is the application of oxalic acid to wall paintings, as well as stone monuments. This method is still under investigation in Italy. After intensive laboratory investigations, some in situ applications on stone monuments were executed. The proposed advantage is the controlled transformation of the uppermost layer of calcium carbonate into oxalate, which is much more resistant to any kind of aggressive environmental attacks. This can be observed on a large number of architectural surfaces with compositional oxalate films. As compared to calcium carbonate, the oxalate is much more resistant to acids. At neutral pH the solubility of calcium oxalate is about two orders of magnitude smaller than that of calcium carbonate. It still has a very low solubility down to pH values of about 2-3. However, the treatment by oxalic acid is completely irreversible... 

Dumontet C, Thieblemont C, Espinouse D, Bouafia F, Hequet O, Salles G, Coiffier B. A prospective study of intensive induction therapy with high-dose consolidation in patients with aggressive non-Hodgkin s lymphoma and two or three adverse prognostic factors. Leukemia. 2000 14(12) 2159-2165. 

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