Confocal surface-enhanced Raman

Park, T Lee, S Seong, G. H Choo, J Lee, E. K Ji, W. H Hwang, S. Y Gweon, D. G and Lee, S. 2005. Highly sensitive signal detection of duplex dye-labelled DNA oligonucleotides in a PDMS microtluidic chip Confocal surface-enhanced Raman spectroscopic study. Lab on a Chip 5 437 2. 

Confocal Surface-Enhanced Raman Microscopy at the Surface of Noble Metals... 

In the following, it will be demonstrated that confocal surface-enhanced Raman microscopy is a powerful tool for exploring optical and spectroscopic properties of molecules adsorbed on silver and gold nanoparticles. It is shown that confocal Raman microscopy coupled with high-resolution electron microscopy has the potential to deliver detailed information about the structure of points of high Raman intensity the so-called hot spots. 

Lee D, Lee S, Seong GH, Choo J, Lee EK, Gweon DG, Lee S (2006) Quantitative Analysis of Methyl Parathion Pesticides in a PDMS Microfluidic Channel Using Confocal Surface-Enhanced Raman Spectroscopy. Appl Spectrosc 60 373-377... 

Suh YD, Schemer GK, Zhu L, Lu HP (2003) Probing nanoscale surface enhanced Raman-scattering fluctuation dynamics using correlated AFM and confocal ultramicroscopy. Ultramicroscopy 97 89-102... 

Cai WB, Ren B, Li XQ, She CX, Liu FM, Cai XW, Tian ZQ (1998) Investigation of surface-enhanced Raman scattering from platinum electrodes using a confocal Raman microscope dependence of surface roughening pretreatment. Surf Sci 406 9-22... 

Fig. 8.1 Raman microspectroscopy as combination of surface-enhanced Raman spectroscopy and confocal microscopy...

Silver and gold nanoparticles were generated electrochemically and investigated with confocal Raman microscopy. The combination of surface-enhanced Raman spectroscopy with confocal microscopy accompanied by subsequent scanning electron microscopy provided an image of the geometrical stmcture of the Raman spots. 

Plieth W, Dietz H, Anders A, Sandmann G, Meixner A, Weber M, Kneppe H (2005) Electrochemical preparation of silver and gold nanoparticles characterization by confocal and surface enhanced Raman microscopy. Surf Sci 597 119... 

Other optical and spectroscopic techniques are also important, including positron annihilation lifetime spectroscopy, spectroscopic ellip-sometry, confocal Raman spectroscopy, and photoluminescence spectroscopy. Surface-enhanced Raman spectroscopy has been made tunable using gold nanorods and strain control on elastomeric PDMS substrates. ... 

The Raman techniques combined with AEM microscopic imaging, as for instance TERS (tip-enhanced Raman scattering) spectroscopy [27], allow to analyze surface nanostructures beyond the diffraction limit, but the cost of the instrumental apparatus is not affordable for any research laboratory. Therefore, in this chapter, the results obtained with those techniques will not be presented, though they increased Raman enhancement factors by up to lO, with the possibility of single-molecule detection. Conversely, confocal micro-Raman apparatus is affordable to every research group allowing SERS investigations with more comparable results. 

The application of confocal Raman microscopy to surface Raman has led to some promising results for transition-metal surfaces that yield weak or negligible field enhancement. High-performance CCD detection provided high SNR, and the confocal sampling reduced the background from the solution or gas over the surface (22, 23). Metals such as platinum, rhodium, and ruthenium... 

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