Condensations copper® chloride

In a 500-mL flask containing a Teflon-covered stirring bar and fitted with a cold-water condenser, topped with a tube leading lo a dry ice trap, l,2-dibromo-l-chloro-l,2,2-trifluoroethane (55.3 g, 0.2 mol), oct-l-ene (11.2g, 0.1 mol), copper chloride mixture (0.1 g), ethanolamine (3 g), and r-BuOH (100 mL) were refluxed, with stirring, for 24 h. After cooling to rt, the mixture was diluted with EtjO and the organic layer separated. Fractionation gave the adduct yield 27 g (70%) bp 88 C. 

General experimental details are as follows.697b It is usual first to mix the carbonyl component with the amine, which is presented as, e.g., hydrochloride or acetate. An appropriate hydrogen ion concentration must be maintained. For the preparation of aminoalkyl compounds that are liable to hydrolysis it is recommended that the water produced be removed by a drying agent or by azeotropic distillation. Dioxan is a suitable solvent, but it is often recommended that acetic acid be added to it. Ketones react better in alcohol with paraformaldehyde. Copper chloride or iron chloride is said to be a useful addition in reactions of acetylenes. Reactions of amines, phenols, and furans, even under mild conditions, may be accompanied by multiple condensation or resinification. 4-Hydroxybenzylamine is reported706 to be obtained in 92% yield when ammonia is led into a mixture of phenol and formaldehyde. 

Rajitha, B., Naveen Kumar, V., Someshwar, R, Venu Madhav, J., Narsimha Reddy, P., Thirupathi Reddy, Y. 2006. Dipyridine copper chloride catalyzed coumarin synthesis via Pechmann condensation under conventional heating and microwave irradiation. ARX/VOC 2006(12) 23-27. 

Copper chloride, Diels-Alder catalyst, 144 Copper oxides, promoters for MA catalyst, 36 Cotton, poly(styrene-alt-MA) grafted, 476 Cotton fabric, MA condensation, 503 Coumaline see a-pyrone Coumaran see 2,3-benzofuran Coumarin, 100... 

Stress corrosion cracking. The 90-10 and 70-30 copper-nickels are resistant to chloride- and sulfide-induced SCC. Some copper-based alloys such as aluminum brass are subject to SCC in the presence of ammonia. In practice, this prevents their use in the air-removal section of power plant condensers. Copper-nickel alloys, however, are resistant to SCC and are commonly used in air-removal sections. 

Reaction.—a too c.c. flask to a short upright condenser (see Fig. 86) and to the upper end of the condensei attach a vertical delivery tube, dipping into an ammoniacal cuprous chloride solution. Pour 2—3 c.c. of ethylene bromide into the flask with 4 times its volume of strong methyl alcoholic potash, which is prepared by boiling methyl alcohol with excess of caustic potash on the water-bath with upright condenser. On gently heating, a rapid evolution of acetylene occurs and the characteristic brown copper compound (C2H,Cu,HjO) is precipitated from the cuprous chloride solution. 

Installation of a different side chain completely alters the pharmacological profile leading to a new class of muscle relaxants. The synthesis begins with copper(II)-promoted di-azonium coupling between furfural (j ) and 3,4-dichlorobenzene-diazonium chloride (15) to give bi aryl aldehyde Next, condensation with 1-aminohydantoin produces the muscle relaxant clodanolene (17). ... 

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