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Compound filtering

Carry out this preparation precisely as described for the a-compound, but instead of zinc chloride add 2 5 g. of anhydrous powdered sodium acetate (preparation, p. 116) to the acetic anhydride. When this mixture has been heated on the water-bath for 5 minutes, and the greater part of the acetate has dissolved, add the 5 g. of powdered glucose. After heating for I hour, pour into cold water as before. The viscous oil crystallises more readily than that obtained in the preparation of the a-compound. Filter the solid material at the pump, breaking up any lumps as before, wash thoroughly with water and drain. (Yield of crude product, io o-io 5 g.). Recrystallise from rectified spirit until the pure -pentacetylglucose is obtained as colourless crystals, m.p- 130-131° again two recrystallisations are usually sufficient for this purpose. [Pg.142]

Fig. 13.6 Preprocessing compound files. Representative substructural exclusion criteria and compound filters used to prune the CRCD database are shown. These were designed to eliminate reactive compounds, toxic materials, and so on. The complete list of exclusion criteria was developed over a number of years in close collaboration with experienced medicinal chemists. Fig. 13.6 Preprocessing compound files. Representative substructural exclusion criteria and compound filters used to prune the CRCD database are shown. These were designed to eliminate reactive compounds, toxic materials, and so on. The complete list of exclusion criteria was developed over a number of years in close collaboration with experienced medicinal chemists.
The application of computational algorithms for compound filtering and clustering is routinely used to eliminate undesired structures on the basis of chemically reactive fimctionalities, predicted liabilities (e.g., frequent hitters, hERG, cyp450 and so forth), or druglike properties. Computational methods are also used to group compoimds on... [Pg.416]

If the host were to display perfect selectivity, the process outlined in Equation (1) need only be carried out once, the solid inclusion compound filtered, guest A released by gentle warming, and the host H would be recycled. This seldom occurs in practice, and one has to perform carefully designed competition experiments in order to establish the selectivity profile of a given host. [Pg.124]

However designed and implemented, the major purpose of compound filtering techniques is to enrich libraries with compounds having desired features, which can be accomplished by both positive and negative selection. [Pg.39]

The variety of reciprocating pumps is indicated by the specific applications for which pumps are used. Among the variety of pumps available can be included deep-well, boiler-feed, condensation, dry-vacuum, wet-vacuum, compound, filter-press, hydraulic-press, creamery, milk, oil, proportioning, fuel-oil, lime, and magma pumps. Some data on the... [Pg.144]

Work on metallic additives has been particularly to the fore in Japan. A process to produce very fine metal fibres has been developed at the Nippon Institute of Technology (NIT), Saitama, Japan, and has been commercialized in a joint venture with NV Bekaert, Belgium, under the name Bekinit KK. Described as coil shaving, it is faster and more versatile than traditional methods. Fibres of 20-100 pm in diameter can be produced from titanium, aluminium, nickel, copper, and stainless steel, which offer improved conductivity in plastics compounds. Filter media, heat-resistant fabrics, and motorcycle silencers are among other potential applications. [Pg.146]

Apply compound filters that were developed based on the knowledge of experienced medicinal chemists... [Pg.61]

In step-5 of Table 1.7, a set of compound filters based on the knowledge of experienced medicinal chemists is applied further reducing the size of the set of poterrtial compounds for acquisition. Examples of these filters include a number of com-poimd characteristics such as mtmber of rings (2-4), molecular weight (200-400),... [Pg.63]

As the absorbent circulates in the SO2 absorber, it accumulates impurities that need to be removed. These include fine ash particles, heat-stable salts, and other soluble compounds. Filters are used to remove the fly ash particles. Sulfates in the scrubbing solution, which result from SO3 and O2 in the gas stream, as well as other heat stable salts, are removed from a slipstream of lean absorbent using a proprietary process. The waste stream from the slipstream treating process is an absorbent-free, slightly alkaline, aqueous salt solution. For most applications, potable water should be suitable for make-up to the process, and general service water for make-up to the prescrubbo (Kirby. 1992). [Pg.597]


See other pages where Compound filtering is mentioned: [Pg.172]    [Pg.172]    [Pg.107]    [Pg.47]    [Pg.47]    [Pg.145]    [Pg.168]    [Pg.169]    [Pg.171]    [Pg.176]    [Pg.176]    [Pg.177]    [Pg.92]    [Pg.589]    [Pg.172]    [Pg.318]    [Pg.355]    [Pg.535]    [Pg.35]    [Pg.38]    [Pg.535]    [Pg.1837]    [Pg.2749]    [Pg.172]    [Pg.29]    [Pg.92]    [Pg.172]    [Pg.87]    [Pg.6]    [Pg.2683]    [Pg.2839]    [Pg.48]    [Pg.300]    [Pg.200]    [Pg.69]    [Pg.1830]    [Pg.157]   
See also in sourсe #XX -- [ Pg.35 , Pg.39 ]




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Compound filters

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